Search Results

You are looking at 1 - 1 of 1 items for

  • Author or Editor: Robert Vigersky x
Clear All Modify Search
Restricted access

Bart Chernow, Robert Vigersky, John T. O'Brian and Leon P. Georges

✓ A 38-year-old man developed secondary adrenal insufficiency as a consequence of intrathecal methylprednisolone administration. Evidence in support of this diagnosis included an absent plasma cortisol response to insulin-induced hypoglycemia, an inadequate adrenal response to exogenous corticotropin stimulation, a typical delayed response to prolonged corticotropin infusion over 3 days, and the finding of an elevated level of prednisolone in the cerebrospinal fluid a full 2 months after its administration. It is therefore recommended that patients receiving intrathecal steroids be carefully observed for the possible development of secondary adrenal insufficiency.