Search Results

You are looking at 1 - 1 of 1 items for

  • Author or Editor: Pieter T. Deckers x
  • Refine by Access: all x
Clear All Modify Search
Restricted access

Annick Kronenburg, Pieter T. Deckers, Esther van den Berg, Monique M. van Schooneveld, Evert-Jan Vonken, Albert van der Zwan, Bart N. M. van Berckel, Maqsood Yaqub, Willem Otte, Catharina J. M. Klijn, and Kees P. J. Braun


Patients with moyamoya vasculopathy often experience cognitive impairments. In this prospective single-center study, the authors investigated the profile of neurocognitive impairment and its relation with the severity of ischemic brain lesions and hemodynamic compromise.


Patients treated in a Dutch tertiary referral center were prospectively included. All patients underwent standardized neuropsychological evaluation, MRI, digital subtraction angiography, and [O]H2O-PET (to measure cerebrovascular reactivity [CVR]). The authors determined z-scores for 7 cognitive domains and the proportion of patients with cognitive impairment (z-score < −1.5 SD in at least one domain). The authors explored associations between patient characteristics, imaging and CVR findings, and cognitive scores per domain by using multivariable linear regression and Bayesian regression analysis.


A total of 40 patients (22 children; 75% females) were included. The median age for children was 9 years (range 1–16 years); for adults it was 39 years (range 19–53 years). Thirty patients (75%) had an infarction, and 31 patients (78%) had impaired CVR (steal phenomenon). Six of 7 cognitive domains scored below the population norm. Twenty-nine patients (73%) had cognitive impairment. Adults performed better than children in the cognitive domain visuospatial functioning (p = 0.033, Bayes factor = 4.0), and children performed better in processing speed (p = 0.041, Bayes factor = 3.5). The authors did not find an association between infarction, white matter disease, or CVR and cognitive domains.


In this Western cohort, cognitive functioning in patients with moyamoya vasculopathy was below the population norm, and 73% had cognitive impairment in at least one domain. The cognitive profile differed between adults and children. The authors could not find an association with imaging findings.