Koji Yoshimoto, Shunji Nishio, Satoshi Suzuki, Masashi Fukui, and Kanehiro Hasuo
Takehiko Baba, Masashi Fukui, Iwao Takeshita, Yuichi Ichiya, Yasuo Kuwabara, and Kanehiro Hasuo
✓ The effect of intravenous and intracarotid administration of adenosine triphosphate (ATP) on the regional blood flow of glioma patients has been examined by means of positron emission tomography. Intracarotid administration of ATP at a dose of 0.52 to 1.3 µg/kg/min selectively increased the blood flow in the tumor by 26.2% ± 10.5% (mean ± standard deviation). The side effects observed were tolerable. In contrast, intravenous administration of ATP failed to increase tumor blood flow. It is suggested that intracarotid administration of ATP may serve to selectively enhance the delivery of anticancer agents to malignant brain tumors.
Takato Morioka, Tadahisa Shono, Shunji Nishio, Kisaku Yoshida, Kanehiro Hasuo, and Masashi Fukui
✓ The authors report a case of bilateral chronic subdural hematoma in a 25-year-old woman who had occipital and neck pain. Magnetic resonance imaging revealed progressive caudal descent of the cerebellar tonsils (acquired Chiari I malformation) and a large eccentric syrinx in the spinal cord from the C3—T7 levels. Spontaneous disappearance of the chronic subdural hematomas resulted in radiographic resolution of both lesions, as well as clinical improvement. Theories of syringomyelia formation, the relationship to acquired Chiari I malformation, and the implications of this case are discussed.