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Jesús Vaquero and José M. Cabezudo

✓ A subgaleal tension aerocele associated with an extracerebral air collection and rhinorrhea is reported. It occurred 3 months after removal of a frontal en plaque meningioma affecting the frontal sinus.

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Gonzalo Bravo, Jesús Vaquero, Roberto Martínez and José Cabezudo

✓ A case of clinically unsuspected mesencephalic tuberculoma that was diagnosed at operation is presented. After intraoperative diagnosis, the surgical procedure was interrupted and specific treatment with tuberculostatic agents was started. The symptoms remitted totally in a few months. This conservative management is preferable to surgical removal when the diagnosis of brain-stem tuberculoma has been established.

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Jesús Vaquero, Carlos Jiménez and Roberto Martínez

✓ A case of presumed cerebral hydatid embolism in the course of cardiac surgery for echinococciasis is reported. Follow-up computerized tomography immediately after embolization, and 1 and 5 years later suggested an average growth pattern of 1 cm/year for intracranial hydatid cysts in the adult.

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Eduardo Rossi, Jesús Vaquero and Roberto Martínez

✓ A rare case of parailiac ectopic bone formation 10 years after a Cloward procedure is presented. Dystrophic calcification of a previous hematoma or deposit of bone dust were considered to be the origin of this unusual complication.

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Jesús Vaquero, José M. Cabezudo and Guillermo Leunda

✓ A case of solitary mesencephalic abscess in a 13-year-old boy is presented. The computerized tomography and clinical pictures, indicating a Weber syndrome and obstructive hydrocephalus, resolved totally 20 days after implantation of a ventriculoatrial shunt and treatment with intravenous chloramphenicol and penicillin. This is the fifth reported case of survival in a patient with a brain-stem abscess, and the first in which this outcome has been achieved without surgical drainage of the abscess.

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Mercedes Zurita, Jesús Vaquero and Isabel Zurita

Object. A glycoprotein, CD95 (Fas/APO1) is widely considered to be implicated in the development of apoptosis in a number of tissues. Based on the hypothesis that apoptosis is related to cell death after spinal cord injury (SCI), the authors studied the presence and distribution of CD95 (Fas/APO1)-positive cells in injured spinal cord tissue for the purpose of determining the significance of this protein during the early phases of SCI.

Methods. The presence and distribution of cells showing positive immunostaining for CD95 (Fas/APO1) were studied 1, 4, 8, 24, 48, and 72 hours and 1, 2, and 4 weeks after induction of experimental SCI in rats. Studies were conducted using a monoclonal antibody to the CD95 (Fas/APO1) protein. Positivity for CD95 (Fas/APO1) was observed in apoptotic cells, mainly in the gray matter, 1 hour after trauma, and the number of immunostained cells increased for the first 8 hours, at which time the protein was expressed in both gray and white matter. From 24 to 72 hours postinjury, the number of immunostained cells decreased in the gray matter, but increased in the white matter. From then on, there were fewer CD95 (Fas/APO1)-positive cells, but some cells in the white matter still exhibited positive immunostaining 1 and 2 weeks after injury. At 4 weeks, there remained no CD95 (Fas/APO1)-positive cells in injured spinal cord.

Conclusions. These findings indicate that CD95 (Fas/APO1) is expressed after SCI, suggesting a role for this protein in the development of apoptosis after trauma and the possibility of a new therapeutic approach to SCI based on blocking the CD95 (Fas/APO1) system.

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Jesús Vaquero, Rafael G. de Sola and Roberto Martínez

✓ A case of lateral sinus pericranii in a 49-year-old woman is presented. These extraordinarily rare lesions should be considered in the differential diagnosis of epicranial tumors. The lack of filling on external carotid artery angiograms may lead to the error of dismissing the possibility of a vascularized lesion.