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Effect of Hypothermia and Hypertonic Urea on Distribution of Intracranial Contents

Hubert L. Rosomoff

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Bilateral Percutaneous Cervical Radiofrequency Cordotomy

Hubert L. Rosomoff

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Experimental Brain Injury During Hypothermia

Hubert L. Rosomoff

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Ethylene Oxide Sterilized, Freeze-Dried Dura Mater for the Repair of Pachymeningeal Defects

Hubert L. Rosomoff

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Distribution of Intracranial Contents after Hypertonic Urea

Hubert L. Rosomoff

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Sleep-induced apnea

Part 1: A respiratory and autonomic dysfunction syndrome following bilateral percutaneous cervical cordotomy

Abbott J. Krieger and Hubert L. Rosomoff

✓ Data are reported on 10 patients who developed a syndrome of sleepinduced apnea preceded by lethargy and asthenia following bilateral percutaneous cervical cordotomy. Respiratory dysfunction occurred within 24 to 48 hours in most cases but appeared as early as 1 hour and as late as 6 days. One type of respiratory dysfunction was characterized by an attenuated CO2 response with a normal vital capacity; in a second type an attenuated CO2 response and a decreased vital capacity were both present. A variety of other autonomic dysfunctions were present in some of the patients; these included hypotension, hyponatremia, inappropriate antidiuretic hormone secretion, and difficulties in micturition. The syndrome lasted from 3 to 32 days in surviving patients. Five patients required endotracheal intubation. Three deaths were attributable to this syndrome; two occurred in patients who were not intubated and died in their sleep. The incidence of apnea during sleep, its reversal by arousal, and the absence of significant motor changes strongly suggest that the ascending reticular fibers in the ventrolateral segment of the spinal cord have been damaged.

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Hypothermia and Cerebral Vascular Lesions

I. Experimental Interruption of the Middle Cerebral Artery During Hypothermia

Lieut. Hubert L. Rosomoff

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Sleep-induced apnea

Part 2: Respiratory failure after anterior spinal surgery

Abbott J. Krieger and Hubert L. Rosomoff

✓ The syndrome of sleep-induced apnea is described in two patients who had anterior spinal surgery at the C3–4 interspace. Postoperatively both had high levels of analgesia, periods of confusion, and signs of respiratory failure at night. The management of occult respiratory failure by endotracheal intubation and assisted ventilation is described, and the associated variations in pulmonary function are discussed.

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Occult Respiratory Dysfunction in a Craniovertebral Anomaly

Abbott J. Krieger, Hubert L. Rosomoff, Abraham S. Kuperman, and Lawrence H. Zingesser

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Effects of Percutaneous Cervical Cordotomy on Pulmonary Function

Hubert L. Rosomoff, Abbott J. Krieger, and Abraham S. Kuperman