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Bharat Guthikonda, Emilie Rouah, Bhuvanaswari Krishnan, Suzanne Z. Powell, J. Clay Goodman, Shankar P. Gopinath and Richard K. Simpson

Whipple disease is a multisystem infectious disease caused by Tropheryma whippleii. It commonly affects the CNS and produces neurological symptoms in 10–20% of cases. Central nervous system Whipple disease occurring in patients with AIDS is extremely rare. The authors present a case of a newly diagnosed AIDS patient in whom intracranial Whipple disease was diagnosed by stereotactic brain biopsy.