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Alessandro Dario, Giuseppe Ottavio Armocida and Davide Locatelli

The authors report the history of the Tabulae Anatomicae of Bartolomeo Eustachio (ca. 1510–1574). In the tables, the anatomical illustrations were drawn inside a numerical frame, with pairs of numbers on the y- and x-axes to identify single anatomical details in the reference table. The measures and the references could be calculated using the graduated margins divided by 5 units for each the x-axis and y-axis. The Tabulae Anatomicae can be considered a precursor to modern anatomical reference systems that are the basis of studies on cerebral localization mainly used for stereotactic procedures.