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  • Author or Editor: Chrysoula Kontrafouri x
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Georgios P. Skandalakis, Spyridon Komaitis, Aristotelis Kalyvas, Evgenia Lani, Chrysoula Kontrafouri, Evangelos Drosos, Faidon Liakos, Maria Piagkou, Dimitris G. Placantonakis, John G. Golfinos, Kostas N. Fountas, Eftychia Z. Kapsalaki, Constantinos G. Hadjipanayis, George Stranjalis and Christos Koutsarnakis


Although a growing body of data support the functional connectivity between the precuneus and the medial temporal lobe during states of resting consciousness as well as during a diverse array of higher-order functions, direct structural evidence on this subcortical circuitry is scarce. Here, the authors investigate the very existence, anatomical consistency, morphology, and spatial relationships of the cingulum bundle V (CB-V), a fiber tract that has been reported to reside close to the inferior arm of the cingulum (CingI).


Fifteen normal, formalin-fixed cerebral hemispheres from adults were treated with Klingler’s method and subsequently investigated through the fiber microdissection technique in a medial to lateral direction.


A distinct group of fibers is invariably identified in the subcortical territory of the posteromedial cortex, connecting the precuneus and the medial temporal lobe. This tract follows the trajectory of the parietooccipital sulcus in a close spatial relationship with the CingI and the sledge runner fasciculus. It extends inferiorly to the parahippocampal place area and retrosplenial complex area, followed by a lateral curve to terminate toward the fusiform face area (Brodmann area [BA] 37) and lateral piriform area (BA35). Taking into account the aforementioned subcortical architecture, the CB-V allegedly participates as a major subcortical stream within the default mode network, possibly subserving the transfer of multimodal cues relevant to visuospatial, facial, and mnemonic information to the precuneal hub. Although robust clinical evidence on the functional role of this stream is lacking, the modern neurosurgeon should be aware of this tract when manipulating cerebral areas en route to lesions residing in or around the ventricular trigone.


Through the fiber microdissection technique, the authors were able to provide original, direct structural evidence on the existence, morphology, axonal connectivity, and correlative anatomy of what proved to be a discrete white matter pathway, previously described as the CB-V, connecting the precuneus and medial temporal lobe.