Charles Y. Liu and Alfredo Quinones-Hinojosa
Robert G. Grossman, Charles Y. Liu, and Amit Verma
Howard M. Eisenberg, Charles Y. Liu, and Oren Sagher
Yvette D. Marquez, Michael Y. Wang, and Charles Y. Liu
Over the course of the past few decades, it has become apparent that in contrast to previously held beliefs, the adult central nervous system (CNS) may have the capability of regeneration and repair. This greatly expands the possibilities for the future treatment of CNS disorders, with the potential strategies of treatment targeting the entire scope of neurological diseases. Indeed, there is now ample evidence that stem cells exist in the CNS throughout life, and the progeny of these stem cells may have the ability to assume the functional role of neural cells that have been lost. The existence of stem cells is no longer in dispute. In addition, once transplanted, stem cells have been shown to survive, migrate, and differentiate. Nevertheless, the clinical utility of stem cell therapy for neurorestoration remains elusive. Without question, the control of the behavior of stem cells for therapeutic advantage poses considerable challenges. In this paper, the authors discuss the cellular signaling processes that influence the behavior of stem cells. These signaling processes take place in the microenvironment of the stem cell known as the niche. Also considered are the implications attending the replication and manipulation of elements of the stem cell niche to restore function in the CNS by using stem cell therapy.
Daniel J. Hoh, Charles Y. Liu, and Michael Y. Wang
Effective methods for fixation of the axis include C1–2 transarticular and C-2 pedicle screw placement. Both techniques pose a risk of vertebral artery (VA) injury in patients with narrow pedicles or an enlarged, high-riding VA. Pars screws at C-2 avoid the pedicle, but can cause VA injury with excessively long screws. Therefore, the authors evaluated various entry points and trajectories to determine ideal pars screw lengths that avoid breaching the transverse foramen.
Both pars were studied on 50 CT scans (100 total). Various pars lengths were assessed using 2 entry points and 3 trajectories (6 measurements). Entry point A was the superior one-fourth of the lateral mass. Entry point B was 3-mm rostral to the inferior aspect of the lateral mass. Using entry points A and B, Trajectory 1 was the minimum distance to the transverse foramen; Trajectory 2 was the maximum distance to the transverse foramen; and Trajectory 3 was the steepest angle to the pars/C-2 superior facet junction without transverse foramen breach.
The mean patient age was 46 ± 17 years, and 84% of the CT scans reviewed were obtained in men. There was no significant difference in right or left measurements. Entry point B demonstrated greater pars lengths for each trajectory compared with entry point A (p < 0.0001). For both entry points, Trajectory 3 provided the greatest pars length. Using Trajectory 3 with entry point B, 84, 95, and 99% had a pars length that measured ≥ 18, 16, and 14 mm, respectively. Using Trajectory 3 with Entry point A, only 41, 64, and 87% had a pars length that measured ≥ 18, 16, and 14 mm, respectively.
Using an entry point 3-mm rostral to the inferior edge of the lateral mass and a trajectory directed toward the superior facet/pars junction, 99% of partes interarticularis in this study would tolerate a 14-mm screw without breach of the transverse foramen.
Charles Y. Liu, Brian Lee, Nicholas Boulis, and Ali R. Rezai
Gabriel Zada, Eisha Christian, Charles Y. Liu, and Steven L. Giannotta
Aneurysms of the anterior communicating artery (ACoA) can be a considerable challenge to treat surgically based on variations in the anatomy and morphological features of the ACoA complex. The fenestrated aneurysm clip can be a simple and practical tool in the operative management of ACoA aneurysms. The goal in this study was to characterize the particular surgical situations in which the use of a fenestrated clip facilitates the clip ligation of ACoA aneurysms.
The authors present their operative strategy and techniques for the use of fenestrated clips in the treatment of ACoA aneurysms.
One hundred ninety-nine patients underwent surgical clipping of an ACoA aneurysm at the authors' institution between the years 1991 and 2008. Of these patients, fenestrated aneurysm clips were used in 20 cases (10%). The following structures were enclosed in the clip aperture: ipsilateral A2 artery, 12 patients (60%); ipsilateral A1 artery, 4 patients (20%); ipsilateral A1 artery plus recurrent artery of Heubner, 1 patient (5%); ACoA, 1 patient (5%); frontopolar artery, 1 patient (5%); and no structures, 1 patient (5%). Aneurysms approached from the left side more frequently required fenestrated clips than did right-sided aneurysms (80 vs 20%, p = 0.0073). In all cases, patency of the A2 vessels was confirmed on postoperative angiography. In 2 patients, small remnant aneurysm necks were identified on postoperative angiography.
The use of fenestrated aneurysm clips can minimize tedious and potentially dangerous dissection of adherent branch vessels, while maintaining the integrity of structures placed within the clip aperture. The ACoA aneurysms pointing in a superior direction are more likely to require clip fenestration around the A2 vessel, whereas those pointing in an inferior direction are more likely to require clip fenestration around the A1 vessel. The parallel approximation of the fenestrated clip blades makes them especially useful in the treatment of large or giant aneurysms.
Christopher J. Stapleton, Charles Y. Liu, and Martin H. Weiss
Growth hormone (GH)–secreting pituitary adenomas represent a common source of GH excess in patients with acromegaly. Whereas surgical extirpation of the culprit lesion is considered first-line treatment, as many as 19% of patients develop recurrent symptoms due to regrowth of previously resected adenomatous tissue or to continued growth of the surgically inaccessible tumor. Although medical therapies that suppress GH production can be effective in the management of primary and recurrent acromegaly, these therapies are not curative, and lifelong treatment is required for hormonal control. Stereotactic radiosurgery has emerged as an effective adjunctive treatment modality, and is an appealing alternative to conventional fractionated radiation therapy. The authors reviewed the growing body of literature concerning the role of radiosurgical procedures in the treatment armamentarium of acromegaly, and identified more than 1350 patients across 45 case series. In this review, the authors report that radiosurgery offers true hormonal normalization in 17% to 82% of patients and tumor growth control in 37% to 100% of cases across all series, while minimizing adverse complications. As a result, stereotactic radiosurgery represents a safe and effective treatment option in the multimodal management of primary or recurrent acromegaly secondary to GH-secreting pituitary adenomas.
Gabriel Zada, Charles Y. Liu, Dawn Fishback, Peter A. Singer, and Martin H. Weiss
The goal of this study was to assess the incidence of symptomatic and occult hyponatremia in patients who had undergone transsphenoidal pituitary surgery.
Patients who underwent transsphenoidal surgery at the University of Southern California University Hospital between 1997 and 2004 had serum sodium levels drawn on an outpatient basis on postoperative Day 7. Patient records were retrospectively reviewed to determine the incidence of, and risk factors for, symptomatic and asymptomatic hyponatremia.
Two hundred forty-one patients had routine serum sodium levels drawn as outpatients on postoperative Day 7. Twenty-three percent of these patients were found to be hyponatremic (Na ≤ 135 mEq/L). The overall incidence rate of symptomatic hyponatremia in the 241 patients was 5%. The majority of hyponatremic patients (80%) remained asymptomatic, whereas 20% became symptomatic. In patients with symptomatic hyponatremia, the mean sodium level at diagnosis was 120.5 mEq/L, compared with 128.4 mEq/L in asymptomatic, hyponatremic patients (p < 0.0001). Female patients were more likely to develop hyponatremia than male patients (33% compared with 22%, p < 0.03). Fifty-two percent of patients who had transient diabetes insipidus (DI) early in their postoperative course subsequently developed hyponatremia, compared with 21% of those who did not have DI (p < 0.001). Patient age, tumor type, and tumor size did not correlate with development of delayed hyponatremia. Outpatients with moderately and severely low sodium levels were 5 and 12.5 times more likely, respectively, to be symptomatic than were patients with mild hyponatremia.
Delayed hyponatremia occurs more frequently than was previously suspected in patients who have undergone transsphenoidal surgery, especially in female patients and those who have previously had transient DI. The majority of hyponatremic patients remain asymptomatic. Obtaining a serum sodium value on an outpatient basis 1 week after pituitary surgery is helpful in recognition, risk stratification, and subsequent intervention, and may prevent potentially serious complications.
Richard G. Fessler, Charles Y. Liu, Stephen McKenna, R. David Fessler, Jane S. Lebkowski, Catherine A. Priest, and Edward D. Wirth III
This study was conducted as a final proof-of-safety direct injection of oligodendrocyte progenitor cells into the uninjured spinal cord prior to translation to the human clinical trials.
In this study, 107 oligodendrocyte progenitor cells (LCTOPC1, also known as AST-OPC1 and GRNOPC1) in 50-μL suspension were injected directly into the uninjured spinal cords of 8 immunosuppressed Göttingen minipigs using a specially designed stereotactic delivery device. Four additional Göttingen minipigs were given Hanks’ Balanced Salt Solution and acted as the control group.
Cell survival and no evidence of histological damage, abnormal inflammation, microbiological or immunological abnormalities, tumor formation, or unexpected morbidity or mortality were demonstrated.
These data strongly support the safety of intraparenchymal injection of LCTOPC1 into the spinal cord using a model anatomically similar to that of the human spinal cord. Furthermore, this research provides guidance for future clinical interventions, including mechanisms for precise positioning and anticipated volumes of biological payloads that can be safely delivered directly into uninjured portions of the spinal cord.