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Bernhard Zünkeler, Richard E. Carson, Jeff Olson, Ronald G. Blasberg, Hetty Devroom, Robert J. Lutz, Stephen C. Saris, Donald C. Wright, William Kammerer, Nicholas J. Patronas, Robert L. Dedrick, Peter Herscovitch and Edward H. Oldfield

p , the plasma volume (milliliter plasma/milliliter tissue); and the local brain arrival time of rubidium-82 after injection. 9, 12, 14, 24, 26 To reduce statistical variability, the K 1 and V p values of matching regions (that is, tumor or perfused brain) from four adjacent PET slices (6.5-mm slice separation) were averaged after region analysis. Results Positron Emission Tomography Analysis Tumor regions were identified in 11 of 18 PET studies and in nine of 13 patients. In the remaining seven studies (Cases 10-13), 82 Rb uptake in the anatomical region of

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John D. Heiss, Nicholas Patronas, Hetty L. DeVroom, Thomas Shawker, Robert Ennis, William Kammerer, Alec Eidsath, Thomas Talbot, Jonathan Morris, Eric Eskioglu and Edward H. Oldfield

expulsion of CSF into the cervical subarachnoid space is the normal compensatory mechanism in response to brain expansion during cardiac systole ( Fig. 8 upper ), brain expansion forces the cerebellar tonsils (as shown on intraoperative ultrasound images) into the partially enclosed spinal subarachnoid space ( Fig. 8 center ). Because the partially enclosed spinal subarachnoid space has low compliance to abrupt changes in volume, tonsillar descent results in enlarged cervical subarachnoid pulse pressure waves, as demonstrated by the results of the CSF pressure