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Diogo Cordeiro, Zhiyuan Xu, Gautam U. Mehta, Dale Ding, Mary Lee Vance, Hideyuki Kano, Nathaniel Sisterson, Huai-che Yang, Douglas Kondziolka, L. Dade Lunsford, David Mathieu, Gene H. Barnett, Veronica Chiang, John Lee, Penny Sneed, Yan-Hua Su, Cheng-chia Lee, Michal Krsek, Roman Liscak, Ahmed M. Nabeel, Amr El-Shehaby, Khaled Abdel Karim, Wael A. Reda, Nuria Martinez-Moreno, Roberto Martinez-Alvarez, Kevin Blas, Inga Grills, Kuei C. Lee, Mikulas Kosak, Christopher P. Cifarelli, Gennadiy A. Katsevman and Jason P. Sheehan

, 37 Other SRS-related adverse effects, such as radiation-induced optic neuropathy and other cranial deficits, have been described. Radiological control of tumor growth has been reported to exceed 90% in most series of patients treated at high-volume centers, while the endocrine remission (a normal hormone level without medical management) is achieved in 50%–60% of patients with Cushing’s disease (CD) and acromegaly. 12 To date, published studies of SRS-induced hypopituitarism have largely been single-center series with a relatively low statistical power and

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some patients showed viral protein, DNA, and RNA including CD, but with viral genes only detected in limited amounts and not in all samples (up to 2000 DNA copies/μg tissue). MRI immediately after injecting Toca 511 plus gadolinium showed imprecise delivery. Therefore, realtime MRI-guided CED was implemented. In 7 patients at a single center (average tumor volume = 10.5 cm3, range=2.6–25.0 cm3) 12–70% of tumor volume (mean=45%) was infused. A 14-gauge cannula allowed flow rates up to 50 microL/min without reflux, and 3.1 mL was delivered to 1–3 targets with improved

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survivors remain disabled. Minimally invasive techniques for ICH removal have shown a positive relationship between hemorrhage volume reduction and patient outcome. We describe our experience with minimally invasive, endoscopic assisted, neuronavigation guided evacuation of ICH using the Apollo system and patient outcomes. Methods: Patients presenting with ICH and treated with the Apollo system since October 2014 were included in this retrospective review. All had a neurovascular study negative for underlying vascular lesion, and were treated using a burr hole