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Kristin Huntoon, Tianxia Wu, J. Bradley Elder, John A. Butman, Emily Y. Chew, W. Marston Linehan, Edward H. Oldfield and Russell R. Lonser

best assess cyst biology and clinical features, patients and peritumoral cysts with less than a 2-year follow-up were excluded. 11 To avoid confounding information, imaging data analysis was terminated in patients and cysts at the initiation of systemic chemotherapy, stereotactic radiosurgery, or craniospinal radiation. 2 , 24 MRI was used to calculate hemangioblastoma (T1-weighted, after contrast addition) and associated cyst (T2-weighted) volume by a modified ellipsoid formula at each visit. 15 Cyst growth patterns were classified as saltatory (growth and

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Russell R. Lonser, John A. Butman, Kristin Huntoon, Ashok R. Asthagiri, Tianxia Wu, Kamran D. Bakhtian, Emily Y. Chew, Zhengping Zhuang, W. Marston Linehan and Edward H. Oldfield

enhancing tumor) postcontrast MRI. Volume assessment values were initially assessed serially by a single observer and confirmed by at least one other observer. Patterns of tumor growth were classified as saltatory (exhibiting periods of growth and growth quiescence), linear, or exponential. Tumors that did not progress in size were classified as stable. Statistical Analysis Descriptive statistics were used to summarize patient characteristics and hemangioblastoma features. To examine the effect of factors, such as age and sex, on tumor growth rate, a linear mixed