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  • By Author: Oldfield, Edward H. x
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Daniel M. Lieberman, Douglas W. Laske, Paul F. Morrison, Krzysztof S. Bankiewicz and Edward H. Oldfield

100 µm:170 µm). The proximal end of the PEEK tube was connected to a 100-µl syringe via a flangeless fitting, female/female coupler, and a Luer lock fitting with zero dead volume. These materials were chosen to minimize the compliance of the infusion system. A silicone coating ‡ was applied to the inner surface of the cannulas before the first use. After the syringe and cannula were flushed with distilled water, the cannula was loaded with 20 µl of solution for infusion through the distal tip by withdrawing the plunger. Rats anesthetized with ketamine (100 mg

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Stephen C. Saris, Daniel R. Shook, Ronald G. Blasberg, Robert L. Dedrick, John L. Doppman, Krzysztof S. Bankiewicz, J. Bob Blacklock and Edward H. Oldfield

with intravenous potassium chloride and sodium pentothal. The brains were rapidly removed and frozen in liquid Freon. The dose of isotope, duration and volume of infusion, administration route, and rate of injection are listed in Table 1 . The control group received intravenous bolus injections of 14 C-IAP followed by sacrifice and rapid brain removal. TABLE 1 Features of intracarotid infusions in eight monkeys * Group Drug Delivery Route Amount of Isotope ( µ Ci) Duration of Infusion (sec) Rate of Infusion (cc/min) Volume