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  • By Author: Lubelski, Daniel x
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protect against dioxin action in vivo, with the ultimate goal of identifying a therapeutic approach to improve bone healing in smokers. Neurosurg Focus Neurosurgical Focus FOC 1092-0684 American Association of Neurological Surgeons 2015.4.FOC-LSRSABSTRACTS Abstract Paper # 25. Large Animal Model Development for Use in Testing a Novel Cell Therapy for Degenerative Disc Disease Lara I. Silverman , PhD , Antwain Howard , DVM , and Kevin Foley , MD Semmes-Murphey Neurologic Institute 4 2015 38

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the non-chondrodystrophic (NCD) or “mongrel” dog that retains its population of notochordal cells (unlike humans) does not develop DDD if at all, until much later in life. Here we demonstrate that NCCM is capable of regenerating the degenerative disc in a pre-clinical animal model of DDD. Materials/Methods: We used a 26-gauge needle and image guidance to develop DDD in a pre-clinical rodent model and characterized the degenerative cascade from healthy through 10-weeks by analyzing the IVD NPs until 6-weeks post injury. Meanwhile we generated notochordal cell

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intervertebral disc (IVD) in animal models induces structural damage and leads to IVD degeneration over time. Prior rodent IVD degeneration models have involved injury to multiple IVDs, which confounds the mechanism of pain generation. This study identifies a behavioral and pain-related sensitivity phenotype after puncture of one lumbar IVD. Materials/Methods: Baseline functional assessments including static weight-bearing, gait analysis, site-specific algesia, and open field testing were done for Sprague-Dawley rats (n=36, 18 weeks old) the day before lumbar IVD