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Mohammed F. Shamji Toronto Western Hospital 4 2013 34 4 Functional Imaging A5 A6 Copyright held by the American Association of Neurological Surgeons. You may not sell, republish, or systematically distribute any published materials without written permission from JNSPG. 2013 Introduction: Intervertebral disc (IVD) herniation causes radiculopathy by mechanical compression and biochemical irritation of nearby neural structures. Animal models of radiculopathy describe demyelination, slowed nerve conduction, and heightened pain sensitivity

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corticosteroids. Conclusion Pre-clinical animal models are essential in demonstrating the safety and efficacy of spinal biologics. Utilizing historical controls, we established the expected arthrodesis rates in the rabbit posterolateral spinal arthrodesis model with varying experimental conditions. Neurosurg Focus Neurosurgical Focus FOC 1092-0684 American Association of Neurological Surgeons 2013.1.FOC-LSRSABSTRACTS Poster Abstract Poster 15. The Impact Of Reduction Of Pain Following Lumbar Spine Surgery: The Relationship Between

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intervertebral disc (IVD) in animal models induces structural damage and leads to IVD degeneration over time. Prior rodent IVD degeneration models have involved injury to multiple IVDs, which confounds the mechanism of pain generation. This study identifies a behavioral and pain-related sensitivity phenotype after puncture of one lumbar IVD. Materials/Methods: Baseline functional assessments including static weight-bearing, gait analysis, site-specific algesia, and open field testing were done for Sprague-Dawley rats (n=36, 18 weeks old) the day before lumbar IVD