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Antonios Mammis, Jean Anderson Eloy and James K. Liu

den Brande. 43 The measurement of endocrine function would later be revolutionized by radioimmunoassays. The physiological mechanisms of the growth hormone and insulin-like growth factor system were eventually understood. Innovations in modern neuroimaging, pituitary surgery, radiotherapy, and medical therapy contributed to the advancements that set the stage for modern medical and surgical management of acromegaly and gigantism. Conclusions Although accounts have appeared in the lay literature for millennia, the recognition of acromegaly and gigantism as