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Alexander P. Marston, Jeffrey T. Jacob, Matthew L. Carlson, Bruce E. Pollock, Colin L. W. Driscoll and Michael J. Link

Knife dose parameters, need for salvage treatment, and hearing status were collected. Radiosurgical data points included tumor volume treated, dose to the tumor margin, maximum tumor dose, and number of isocenters. Tumor size, location, and hearing outcomes were reported according to the 1995 American Academy of Otolaryngology–Head and Neck Surgery (AAO-HNS) guidelines. 5 Patients with serviceable hearing (Class A or B) at the time of SRS were included in audiometric analysis. Tumor measurements were made on axial T1-weighted post-Gd MRI scans by an otolaryngologist

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Brian A. Neff, Matthew L. Carlson, Megan M. O'Byrne, Jamie J. Van Gompel, Colin L. W. Driscoll and Michael J. Link

approach; tumor resection completeness; inadvertent intraoperative fifth nerve injury (partial or complete transection); presence of a compressive vessel on the trigeminal nerve; concurrent microvascular decompression with tumor removal; postoperative neuralgia, numbness, or paresthesia outcome; time until symptom improvement; tumor size; cystic nature of tumor; pain medication reduction; SRS treatment details including treatment volume, central and marginal dose, number of isocenters, surgical and radiation complications (e.g., facial paralysis); and duration of follow

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Matthew L. Carlson, Jeffrey T. Jacob, Bruce E. Pollock, Brian A. Neff, Nicole M. Tombers, Colin L. W. Driscoll and Michael J. Link

; tumor characteristics (laterality, location [extent of internal auditory canal and CPA involvement], size, volume, macrocystic features, distance to fundus, and brainstem contact); NF2 status; history of prior tumor treatment; and basic demographic information (age and sex). Pretreatment tumor size, location, and hearing capacity were reported according to the 1995 AAO-HNS guidelines. 4 Patients with serviceable hearing (AAO-HNS Class A or B) prior to SRS who received low-dose (12- to 13-Gy marginal dose) SRS between 1997 and 2002 were identified. Preliminary

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Neil S. Patel, Matthew L. Carlson, Bruce E. Pollock, Colin L. W. Driscoll, Brian A. Neff, Robert L. Foote, Christine M. Lohse and Michael J. Link

. Unique to this series is serial measurement of tumor size using 3D tumor segmentation to provide an accurate assessment of tumor progression that avoids error introduced by volume approximation formulae or linear measurements. Three-dimensional volumetric segmentation is particularly advantageous for JP, where the amorphous and infiltrative growth pattern renders other methods imprecise. Methods Data Collection Following Mayo Clinic IRB approval, a retrospective review of paper and electronic medical records for all patients with a diagnosis of JP treated with GKRS was

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Neil S. Patel, Matthew L. Carlson, Bruce E. Pollock, Colin L. W. Driscoll, Brian A. Neff, Robert L. Foote, Christine M. Lohse and Michael J. Link

. Unique to this series is serial measurement of tumor size using 3D tumor segmentation to provide an accurate assessment of tumor progression that avoids error introduced by volume approximation formulae or linear measurements. Three-dimensional volumetric segmentation is particularly advantageous for JP, where the amorphous and infiltrative growth pattern renders other methods imprecise. Methods Data Collection Following Mayo Clinic IRB approval, a retrospective review of paper and electronic medical records for all patients with a diagnosis of JP treated with GKRS was

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Lucas P. Carlstrom, Jeffrey T. Jacob, Christopher S. Graffeo, Avital Perry, Michael S. Oldenburg, Robert L. Foote, Bruce E. Pollock, Colin L. Driscoll, Matthew L. Carlson and Michael J. Link

I n the 3 decades since its mainstream clinical introduction, stereotactic radiosurgery (SRS) has undergone an exponential increase in utilization for a wide swath of benign and malignant intracranial and skull base lesions. For vestibular schwannoma (VS), single-fraction SRS delivers therapeutic radiation to the tumor volume with a steep dose gradient falloff, thereby minimizing the potential for injury to the adjacent and potentially radiosensitive inner ear structures. Previous studies have identified several significant risk factors for hearing loss after

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Hirofumi Nakatomi, Jeffrey T. Jacob, Matthew L. Carlson, Shota Tanaka, Minoru Tanaka, Nobuhito Saito, Christine M. Lohse, Colin L. W. Driscoll and Michael J. Link

this variance can be explained by differences in study definitions and surveillance practices. It is commonly held that extent of resection influences risk of recurrence. However, the definitions of partial, subtotal, near-total, and GTR can vary substantially between studies. For example, some authors quantify STR as more than 5% residual tumor volume, which can be very large when considering a 5-cm tumor, whereas others specify a greater than 2 × 5 × 5–mm remnant volume. 3 , 5 , 8 , 11 , 13 The method and frequency of radiological follow-up is also critical when

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William R. Schmitt, Jasper R. Daube, Matthew L. Carlson, Jayawant N. Mandrekar, Charles W. Beatty, Brian A. Neff, Colin L. Driscoll and Michael J. Link

study . Otolaryngol Head Neck Surg 89 : 767 – 775 , 1981 16 Isaacson B , Kileny PR , El-Kashlan H , Gadre AK : Intraoperative monitoring and facial nerve outcomes after vestibular schwannoma resection . Otol Neurotol 24 : 812 – 817 , 2003 17 Kartush JM , Niparko JK , Bledsoe SC , Graham MD , Kemink JL : Intraoperative facial nerve monitoring: a comparison of stimulating electrodes . Laryngoscope 95 : 1536 – 1540 , 1985 18 Kirkpatrick PJ , Tierney P , Gleeson MJ , Strong AJ : Acoustic tumour volume and the

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Avital Perry, Christopher S. Graffeo, Lucas P. Carlstrom, Aditya Raghunathan, Colin L. W. Driscoll, Brian A. Neff, Matthew L. Carlson, Ian F. Parney, Michael J. Link and Jamie J. Van Gompel

c9fbf 14 de Vries M , Hogendoorn PC , Briaire-de Bruyn I , Malessy MJ , van der Mey AG : Intratumoral hemorrhage, vessel density, and the inflammatory reaction contribute to volume increase of sporadic vestibular schwannomas . Virchows Arch 460 : 629 – 636 , 2012 10.1007/s00428-012-1236-9 15 Edin S , Wikberg ML , Dahlin AM , Rutegård J , Öberg Å , Oldenborg PA , : The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer . PLoS One 7 : e47045

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Øystein Vesterli Tveiten, Matthew L. Carlson, Frederik Goplen, Erling Myrseth, Colin L. W. Driscoll, Rupavathana Mahesparan, Michael J. Link and Morten Lund-Johansen

: a comparison of rates of facial nerve and hearing preservation . Clin Otolaryngol 33 : 228 – 235 , 2008 10.1111/j.1749-4486.2008.01715.x 18559028 29 Meyer TA , Canty PA , Wilkinson EP , Hansen MR , Rubinstein JT , Gantz BJ : Small acoustic neuromas: surgical outcomes versus observation or radiation . Otol Neurotol 27 : 380 – 392 , 2006 10.1097/00129492-200604000-00015 16639278 30 Milligan BD , Pollock BE , Foote RL , Link MJ : Long-term tumor control and cranial nerve outcomes following Gamma Knife knife surgery for larger-volume