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Melanie G. Hayden Gephart, Bonnie P. Taft, Anne-Katrin Giese, Raphael Guzman and Michael S. B. Edwards

dexamethasone: 4 mg intravenously every 6 hours to 1 mg by mouth twice a day. Postoperative Course He recovered well from the reresection; however, because of preoperative lower cranial neuropathies, he returned to the operating room 1 week later for tracheostomy and gastrostomy tube placement. Both intra- and perioperatively, he again exhibited persistent hypertension along with new-onset seizures and alterations in his mental status. Aggressive antihypertension therapy was begun, and levetiracetam was administered. An urgent MR imaging study revealed T2 signal

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Arjun V. Pendharkar, Raphael Guzman, Robert Dodd, David Cornfield and Michael S. B. Edwards

. 5 The 2009 guidelines for the management of SAH suggest using Lindegaard ratios (ratio of the velocity in the brain vessel of choice to the velocity in the ipsilateral extracranial ICA) to follow vasospasm. A Lindegaard ratio of 5–6 for the supraclinoid ICA, ACA, MCA, and vertebrobasilar system has been shown to indicate severe vasospasm. 1 Current treatment modalities aim to reverse the reduction in cerebral blood flow following vasospasm. 17 , 18 Reportedly, the HHH regimen (hypertension, hypervolemia, and hemodilution therapy) is effective for this purpose

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Robert M. Lober, Raphael Guzman, Samuel H. Cheshier, Douglas R. Fredrick, Michael S. B. Edwards and Kristen W. Yeom

gliomatosis in NF1-associated tumors by using MRI-DT imaging. Further studies will be required to determine if the various tractography fiber arrangements, for example, as seen with the prechiasmatic lesions in Fig. 2 , correspond to these known histopathological variants. Our preliminary data as of this writing, previously presented only in abstract form (see end matter), suggest that diffusion characteristics may differentiate indolent lesions from those more likely to progress and require therapy, whereas previous imaging modalities have failed. At present, it remains

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Katie L. Pricola, Jason Karamchandani, Hannes Vogel, Gary V. Dahl, Kristen W. Yeom, Michael S. B. Edwards and Raphael Guzman

histiocytosis is associated with therapy intensification . Blood 111 : 2556 – 2562 , 2008 10 Howarth DM , Gilchrist GS , Mullan BP , Wiseman GA , Edmonson JH , Schomberg PJ : Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome . Cancer 85 : 2278 – 2290 , 1999 11 Irving RM , Broadbent V , Jones NS : Langerhans' cell histiocytosis in childhood: management of head and neck manifestations . Laryngoscope 104 : 64 – 70 , 1994 12 Johnson KK , Dannenbaum MJ , Bhattacharjee MB , Illner A , Dauser

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Melanie G. Hayden Gephart, Robert M. Lober, Robert T. Arrigo, Corinna C. Zygourakis, Raphael Guzman, Maxwell Boakye, Michael S. B. Edwards and Paul G. Fisher

, Montes JL , Atkinson J , Farmer JP , Freeman CR : Adjuvant radiotherapy in the treatment of pediatric myxopapillary ependymomas . Pediatr Blood Cancer 55 : 639 – 643 , 2010 2 Allen JC , Miller DC , Budzilovich GN , Epstein FJ : Brain and spinal cord hemorrhage in long-term survivors of malignant pediatric brain tumors: a possible late effect of therapy . Neurology 41 : 148 – 150 , 1991 3 Becker LE : An appraisal of the World Health Organization classification of tumors of the central nervous system . Cancer 56 : 7 Suppl 1858