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James E. Boggan, Robert Walter, Michael S. B. Edwards, Janis K. Borcich, Richard L. Davis, Michael Koonce and Michael W. Berns

A lthough primary malignant brain tumors are usually well localized lesions that tend to recur locally, the results of treatment are generally poor. 2, 17, 28, 32 Photoradiation therapy performed with the photosensitizing agent, hematoporphyrin derivative (HPD), and laser light have been used successfully to treat a number of non-neural malignancies. 7, 8, 12, 16 Like other protein-bound drugs, it is thought that the photosensitizer, hematoporphyrin, and its derivatives cannot cross the intact blood-brain barrier (BBB), but can diffuse into brain tumors in