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Oral Presentations

2010 AANS Annual Meeting Philadelphia, Pennsylvania May 1–5, 2010

, Canada) 8 2010 113 2 A420 A420 This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose. 2010 Introduction: Our previous studies on a mouse model showed that endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) uncoupling plays a role in vasospasm after subarachnoid hemorrhage (SAH). Simvastatin may decrease vasospasm in both patients and an animal model of SAH. This study investigated the link between the beneficial effect of simvastatin with eNOS/NO uncoupling

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, with >90% of cells confirmed to have EC identity on flow cytometry (CD45-CD31+). These cells were also significantly enriched for EC-related genes such as Cdh5, Icam2, Nos3 and Pecam1. Microarray results will provide a list of genes that are significantly upregulated or downregulated in BECs after SAH, requiring further validation studies. Conclusion: BBB disruption is greater at 24h than at 48h in an experimental SAH model. This study is the first to provide whole genome expression profiling of freshly-isolated BECs derived from an SAH animal model. Thereby

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extracellular water content of brain for improved MR imaging. Preclinical safety testing in a large brain, animal model is now complete, and a clinical trial is being designed to assess the feasibility in patients with movement disorders. J Neurosurg Journal of Neurosurgery JNS 0022-3085 1933-0693 American Association of Neurological Surgeons 2015.6.JNS.AANS2014ABSTRACTS Philip L. Gildenberg Resident Award 639. Brain Computer Interface Technology for Patients Suffering Disorder of Consciousness Robert Prueckl , (Schiedlberg

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spinal fusion, which has became the standard of care. With reducing trend of autograft, BMP and newer bone grafts able to reduce infection rate and improve bony fusion. J Neurosurg Journal of Neurosurgery JNS 0022-3085 1933-0693 American Association of Neurological Surgeons 10.3171/2017.4.JNS.AANS2017abstracts 2017.4.JNS.AANS2017ABSTRACTS Oral Presentations 508. Brain repair and neural network remodeling by hematopoietic growth factors in subacute phase of traumatic brain injury in animal model Gentian Toshkezi