Search Results

You are looking at 1 - 3 of 3 items for

  • Author or Editor: Raymond Sawaya x
  • By Author: Zuccarello, Mario x
Clear All Modify Search
Restricted access

Raymond Sawaya, Mario Zuccarello and Robert Highsmith

✓ This study was undertaken to confirm the presence of alpha-1-antitrypsin (α 1-AT) in human brain tumors and to attempt to elucidate its significance. Seventy-seven consecutive unselected patients with various brain tumors were entered in this study. The α 1-AT and α 2-macroglobulin contents of the tumor extracts were qualitatively assessed by Ouchterlony immunodiffusion techniques. Plasminogen activator (PA) activity was assayed electrophoretically on sodium dodecyl sulfate gels. The patients were divided into two groups according to the positivity of their tumors to α 1-AT. Sixty-eight percent of the tumors were positive for α 1-AT, and all specimens were negative for α 2-macroglobulin. Clinical and biological parameters obtained in all study patients failed to show statistically significant differences between the two groups with the exception of PA activity (p = 0.001), the peritumoral edema as seen on computerized tomography, and the preoperative serum fibrinogen level. These three parameters were higher in the group with specimens positive to α 1-AT.

This study supports the hypothesis that α 1-AT is produced primarily by tumor cells in proportion to the regional proteolytic and inflammatory activity, and may protect the tumor cells.

Restricted access

Mario Zuccarello, Raymond Sawaya, Robert Lukin and Gabrielle deCourten-Myers

✓ A 24-year-old man developed a spontaneous cerebellar hematoma 5 years after the implantation of cerebellar electrodes. No vascular malformations were found either intraoperatively or radiographically. The histopathological findings of the cerebellar tissue obtained at biopsy from the region surrounding the electrodes support the hypothesis of a causal relationship between the spontaneous cerebellar hemorrhage and chronic cerebellar stimulation.