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Yoshikazu Ogawa and Teiji Tominaga

1 patient with a small remnant in the cavernous sinus. Aggressive removal was suspended in 1 patient because intraoperative histological examination had revealed pachymeningitis. Head CT scanning performed the morning of postoperative Day 1 revealed that most cavities of the sellae were occupied with CSF, so-called empty sellae. No patient experienced massive abnormal bleeding throughout the hospital course. Comparison of the antithrombotic agent group and the control group found no difference in preoperative tumor volume (antithrombotic agent group vs control: 2

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Masaki Iwasaki, Nobukazu Nakasato, Hiroyoshi Suzuki and Teiji Tominaga

gabapentin, carbamazepine, and valproate. He had no history of febrile seizures or family history of epilepsy. He was referred to us by his neurologist for the evaluation of surgical treatment. We obtained T1-weighted and FLAIR 1.5-T MR images (1.5-T Signa Excite, GE Healthcare; TR 500 msec, TE 14.5 msec; and TR 11,002 msec, TE 127 msec, and TI 2200 msec, respectively), which showed probable volume loss and increased T2 signal intensity in the right hippocampus ( Fig. 1A and B ). The STIR 3-T MR images (3T Signa Excite, GE Healthcare; TR 5200 msec, TE 34.9 msec, and TI

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Hiroshi Karibe, Hiroaki Shimizu, Teiji Tominaga, Keiji Koshu and Takashi Yoshimoto

with hemiparesis resulting in impairment of motor function. The outcome may be related to age, hematoma volume, depressed level of consciousness, or increased blood pressure. 9, 14, 17, 29, 30, 37 However, most analysis of prognostic indicators has focused on the prediction of early deterioration and death. Prediction of motor impairment would be clinically valuable, especially for the determination of therapeutic strategy. Motor impairment in patients with deep ICH may principally depend on the severity of corticospinal tract injury, so early evaluation of such

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Yosuke Akamatsu, Hiroaki Shimizu, Atsushi Saito, Miki Fujimura and Teiji Tominaga

μm. The diameter of the ICA is approximately 200 μm, and the diameters of the origins of the MCA and the ACA are approximately 170 μm in C57Bl/6 mice under physiological conditions; 9 therefore, we selected this type of suture for complete blocking of the ICA bifurcation when the tip of the suture was correctly placed in the ACA. Surgical Procedure The mice were anesthetized with a ketamine-xylazine mixture (40 mg/kg ketamine and 4 mg/kg xylazine, total volume of injection 1.0 ml/kg intramuscular) and breathed room air spontaneously. The rectal temperature

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Takashi Inoue, Hiroaki Shimizu, Miki Fujimura, Atsushi Saito and Teiji Tominaga

Angiography Magnetic resonance angiography was performed using a whole-body 1.5-T MRI scanner (General Electric Medical Systems) and a parallel imaging head coil. All patients underwent 3D time-of-flight MRA using the following parameters: repetition time 29 msec, echo time 6.9 msec, matrix 128 × 256, FOV 160 mm, and 1.2 mm thickness × 40 slices × 2 slabs (overwrap 8 slices). The data were transferred to a workstation connected to the scanner and were then processed using a 3D volume rendering algorithm. The 3D volume rendering setting was selected, assuming that the

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Tomomi Kimiwada, Toshiaki Hayashi, Ayumi Narisawa, Reizo Shirane and Teiji Tominaga

assessed postoperatively regarding any improvement or worsening of preoperative symptoms, the occurrence of intracranial hypertension requiring subsequent shunt placement, and changes in cyst volume. All patients were evaluated via CT and/or MRI studies pre- and postoperatively. Results Patient Characteristics There were 26 patients with middle cranial fossa arachnoid cysts at the time of fenestration ( Table 1 ). This patient population included 17 males and 9 females, with an age range from 9 months to 15 years (median 7.8 years). Clinical manifestations on

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Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Ken-ichi Nagamatsu, Mika Watanabe and Teiji Tominaga

dexamethasone was also used during infusion. Magnetic resonance images were obtained during and after infusion. Noncontrast T1-weighted MR imaging revealed the delivery of Gd-DOTA that was mixed in the infusion solution ( Fig. 3D–G ). The volume of distribution was plotted against the volume of infusion ( Fig. 3H ). We calculated the volume of distribution as the volume of distribution from MR images containing at least 10% of the total increase in signal intensity due to the addition of contrast agent as reported previously. 13 The images in Fig. 4 (A–D) demonstrate the

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Tomohiro Kawaguchi, Atsuhiro Nakagawa, Toshiki Endo, Miki Fujimura, Yukihiko Sonoda and Teiji Tominaga

, so that strategies to avoid bleeding are extremely important. Water jet dissection has been used in liver and kidney surgery since the 1980s. 4 , 5 , 12–14 This technique initially used high-pressure continuous flow and could dissect tissue but preserve the vasculature, resulting in reductions in blood loss, operative time, and surgical complications. 9 , 12 , 19 , 20 However, the continuous-flow water jet device has several problems to be resolved, because a high volume of water supply is required for dissection, and the consequent water vortex tends to

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Yasuo Nishijima, Kuniyasu Niizuma, Miki Fujimura, Yosuke Akamatsu, Hiroaki Shimizu and Teiji Tominaga

hypoplastic PCoA. 1 This finding showed that the 4-mm suture seemed sufficient to obstruct the origin of the PCA and induce unilateral hippocampal ischemia. Each mouse was anesthetized with a ketamine-xylazine mixture (40 mg/kg ketamine and 4 mg/kg xylazine, total volume of injection 1.0 ml/kg intraperitoneally) and breathed room air spontaneously. Rectal temperature during all surgical procedures was maintained at 36.0°C–37.5°C using a feedback-regulated heating pad (BWT-100; Bio Research Center Co., Ltd.). Arterial blood pressure was measured using the tail-cuff auto

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Toshiyuki Takahashi, Teiji Tominaga, Noriaki Watabe, A. Toshimitu Yokobori Jr., Hiroshi Sasada and Takashi Yoshimoto

phosphate-buffered saline (PBS), either 5 or 50 µg of rhBMP-2 in an equal volume was pipetted over the porous HA graft and allowed to dry beneath a laminar flow in a sterile hood. An equal volume of PBS was applied on the control graft. Animal Model and Surgical Procedure Fourteen female goats, each weighing between 40 and 55 kg, were used in this study after an average of 14 days of preconditioning. All goats underwent a surgical procedure in which sterile techniques were used after the induction of endotracheal anesthesia (a halothane and oxygen gas mixture