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Rare giant cell ependymoma in an octogenarian

Case report and review of the literature

Patrick B. Cooper, Matthew Katus, Leon Moores, Dennis Geyer, James G. Smirniotopoulos, Glenn D. Sandberg and Elisabeth J. Rushing

eosinophilic cytoplasm and dense fibrillary processes ( Fig. 2A ). Several vessels with thickened, hyalinized walls were noted. Definitive perivascular pseudorosettes or true rosettes were not observed. Areas of mitosis, vascular proliferation with endothelial hyperplasia, or necrosis were not seen. An analysis of frozen sections indicated a low-grade glial or mixed glial–neuronal neoplasm, possibly a PXA. The biopsy specimen, which included additional nonfrozen tissue, was fixed using formalin, routinely processed, and embedded in paraffin. Five-micrometer paraffin