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Elad I. Levy, Adnan H. Siddiqui and L. Nelson Hopkins

high rate of recurrent stroke. 4 This has resulted in reinvigoration of endovascular strategies for revascularization of intracranial stenoses. 8 , 9 , 11 , 14 , 21 , 23 , 24 , 26 There are an increasing number of devices specifically designed to meet the challenges of an inhospitable intracranial vasculature and that may be useful for the treatment of intracranial stenoses. The Stenting vs Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis and Vitesse Intracranial Stent Study for Ischemic Therapy trials are underway to explore

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R. Loch Macdonald

O ne of the few groups investigating intracranial aneurysm hemodynamics reports in silico modeling of changes in computational fluid dynamics (CFD) of cerebral aneurysms after treatment with flow-diverting stents. 7 The authors describe 3 patients with intracranial aneurysms treated with flow-diverting Pipeline Embolization Devices (PEDs). They calculated aneurysm flow velocity, inflow rate, wall shear stress ([WSS]; a measure of change in flow into the aneurysm) and turnover time (a measure of stasis in the aneurysm) before and after placement of the PED

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J Mocco, Ricardo A. Hanel, Jitendra Sharma, Erik F. Hauck, Kenneth V. Snyder, Sabareesh K. Natarajan, Italo Linfante, Adnan H. Siddiqui, L. Nelson Hopkins, Alan S. Boulos and Elad I. Levy

used similar stent systems with comparable technical profiles and delivery systems, manufactured by the same company (Wingspan and Neuroform stent systems, Boston Scientific). The Wingspan system is intended for intracranial stenosis treatment and the Neuroform system for aneurysm neck reconstruction. Recently, a new self-expanding stent has become available to the endovascular community, the Enterprise Vascular Reconstruction Device (Codman Neurovascular/Cordis Corp.). This device uses a catheter-based delivery system that has been suggested to provide improved

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Mandy J. Binning, Alexander A. Khalessi, Adnan H. Siddiqui, L. Nelson Hopkins and Elad I. Levy

critical first step in what may prove a promising line of inquiry: stent placement for the treatment of traumatic intracranial dissections in children. Disclosure Dr. Hopkins receives research study grants from Abbott (ACT 1 Choice), Boston Scientific (CABANA), Cordis (SAPPHIRE WW), and ev3 (CREATE) and a research grant from Toshiba (for the Toshiba Stroke Research Center); receives royalties from Cordis (for the Angioguard device); has an ownership/financial interest in AccessClosure, Boston Scientific, Micrus, and Valor Medical; serves on the Abbott Vascular

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Ashish Sonig, Hussain Shallwani, Bennett R. Levy, Hakeem J. Shakir and Adnan H. Siddiqui

is a field populated by 3 different specialties: neurosurgery, neurology, and neuroradiology. Furthermore, there is no mandate for academic productivity by any of the participating societies, which stands in contrast to the standard for residency training programs that have research criteria that need to be met prior to the graduation of their residents. To meet the needs of this rapidly evolving field, including the evaluation of indications, techniques, and devices, in addition to expanding horizons to new paradigms, research should be embraced as a foundational

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Aneela Darbar, Richard T. Stevens, Adnan H. Siddiqui, James S. McCasland and Charles J. Hodge

phenytoin at 10–20 μg/ml. Monitoring for Adverse Effects. Animals were observed daily for adverse effects of both drug treatments, and no significant persistent behavioral effects were noted other than minimal lethargy after the first dose of phenytoin and transient increase in whisking for a short time after the D-amphetamine injections. Intrinsic Optical Signal Imaging Data Collection. A charge-coupled device (CCD) camera fitted with an inverted lens system was positioned vertically over the barrel cortex. 58 The surface of the cortex was illuminated by

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Daniel H. Sahlein, Mohammad Fouladvand, Tibor Becske, Isil Saatci, Cameron G. McDougall, István Szikora, Giuseppe Lanzino, Christopher J. Moran, Henry H. Woo, Demetrius K. Lopes, Aaron L. Berez, Daniel J. Cher, Adnan H. Siddiqui, Elad I. Levy, Felipe C. Albuquerque, David J. Fiorella, Zsolt Berentei, Miklos Marosfoi, Saruhan H. Cekirge, David F. Kallmes and Peter K. Nelson

“ophthalmoparesis” should be grouped with subjective findings such as “diplopia.” In April 2011, the Pipeline Embolization Device (PED, Covidien) received FDA clearance for the endovascular reconstruction of large and giant wide-necked aneurysms of the ICA. The safety and efficacy of the PED has been unequivocally demonstrated for these aneurysms of the cavernous and supraclinoid segments of the ICA. 2 , 10 Although the treatment of large and giant ICA aneurysms with mass-occupying coils is very frequently associated with negative neuroophthalmological outcomes 17 —observed

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Jianping Xiang, Robert J. Damiano, Ning Lin, Kenneth V. Snyder, Adnan H. Siddiqui, Elad I. Levy and Hui Meng

T he prevalence of intracranial aneurysms is estimated to be 1%–5% in the general population. 19 , 20 Aneurysm rupture leads to subarachnoid hemorrhage, and can result in devastating morbidity and mortality as well as high health care costs. 20 Flow diversion via flow diverters (FDs) such as the Pipeline Embolization Device (PED, Covidien) is a novel therapeutic method for the treatment of complex intracranial aneurysms, which can be challenging for both conventional microsurgical and endovascular techniques. The PED is a self-expandable, braided, mesh

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Sabareesh K. Natarajan, Ning Lin, Ashish Sonig, Ansaar T. Rai, Jeffrey S. Carpenter, Elad I. Levy and Adnan H. Siddiqui

review board approval, a retrospective review of a prospectively collected database of endovascular patients was performed to identify consecutive patients with VB artery aneurysms who were treated with the Pipeline Embolization Device (PED; Covidien) between May 2011 and February 2014, subsequent to our previously reported series. 17 A total of 12 patients were identified. The electronic charts of these patients were reviewed, and demographic and procedural data were analyzed. In each case, flow diversion was chosen for treatment after the exclusion of all other

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Hajime Ohta, Sabareesh K. Natarajan, Erik F. Hauck, Alexander A. Khalessi, Adnan H. Siddiqui, L. Nelson Hopkins and Elad I. Levy

, were deployed by telescoping techniques. Most dissections were treated with a closed-cell CA stent (Wallstent or Magic Wallstent, Boston Scientific), except those in a tortuous extracranial CA or an intracranial segment. Other stents used were CA stents (Xpert [Abbott Vascular Devices], Xact [Abbott Vascular Devices], and Precise [Codman Neurovascular]), intracranial self-expanding stents (Wingspan [Boston Scientific], Neuroform [Boston Scientific], and Enterprise [Codman Neurovascular]), coronary balloon-mounted stents (Multilink miniVision [Abbott Vascular Devices