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. 2015 Introduction BRAF mutations in melanoma confer a worse prognosis with CNS diseases often serving as a terminal event. In this study we: 1] Compared the incidence of metastatic disease to the brain and the time to development of CNS metastases in patients with BRAFV600E mutations vs. wtBRAF, 2] Attempted to determine differences in outcome between patients with surgery and/or radiation therapy, and 3] assessed the effect of BRAF inhibitor therapy on the incidence of brain metastases. Methods Retrospective review of all melanoma patients who