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Mitsunori Matsumae, Ron Kikinis, István Mórocz, Antonio V. Lorenzo, Marilyn S. Albert, Peter McL. Black and Ferenc A. Jolesz

volunteers were that at the time of the study volunteers had to be free of any severe neurological and psychiatric disorders including drug abuse or alcoholism. Ventricular enlargement due to AS was distinguished on MR images by the usual criteria: normal fourth ventricle and enlarged third and lateral ventricles, associated with absence of CSF flow void in the sylvian aqueduct. Cases of OH included two germ-cell tumors in the pineal region, two pineoblastomas, one cerebellar astrocytoma, one cerebellar meningioma, and one pontine glioma. They had a clinical syndrome of

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Mitsunori Matsumae, Ron Kikinis, István A. Mórocz, Antonio V. Lorenzo, Tamás Sándor, Marilyn S. Albert, Peter McL. Black and Ferenc A. Jolesz

have been provided previously. 1 The other 26 participants were selected from our own database, and although they did not undergo laboratory or neuropsychological testing as did those from the normative aging study, they were deemed to be free of any severe cardiovascular, neurological, or psychiatric disorder, including drug abuse and alcoholism. Magnetic Resonance Imaging Procedures Magnetic resonance images of the brain were obtained on a 1.5-tesla imaging system (Signa; General Electric Corp., Milwaukee, WI) using double-echo (echo times 30 and 80 msec