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  • By Author: Ivan, Michael x
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Oral Presentations

2010 AANS Annual Meeting Philadelphia, Pennsylvania May 1–5, 2010

patient was unaccounted. The median preoperative tumor volume was 57.0 cm 3 and most tumors (N = 206) occupied eloquent territories. All patients underwent resection followed by chemotherapy and radiation therapy. The median postoperative tumor volume was 1.4 cm 3 , equating to a 98% EOR. The median overall survival was 12.2 months. Using Cox proportional hazards analysis, the following were predictive of survival: patient age, KPS, and EOR (p less than 0.0001). A significant survival advantage was seen with as little as 70% EOR, and stepwise improvement in survival

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some patients showed viral protein, DNA, and RNA including CD, but with viral genes only detected in limited amounts and not in all samples (up to 2000 DNA copies/μg tissue). MRI immediately after injecting Toca 511 plus gadolinium showed imprecise delivery. Therefore, realtime MRI-guided CED was implemented. In 7 patients at a single center (average tumor volume = 10.5 cm3, range=2.6–25.0 cm3) 12–70% of tumor volume (mean=45%) was infused. A 14-gauge cannula allowed flow rates up to 50 microL/min without reflux, and 3.1 mL was delivered to 1–3 targets with improved