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without written permission from JNSPG. 2014 Introduction Pediatric low grade astrocytomas are a diverse group of tumors. We have previously shown that pediatric gliomas have BRAF mutations, specifically a BRAF V600E mutation and BRAF fusion genes. KIAA1549 was the first fusion partner identified in gliomas and recently several other partners have been found. BRAF inhibitors showed exciting results in treating V600E-dependent melanomas. We investigated the efficacy of the BRAF inhibitor PLX4720 against

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. 2015 Introduction BRAF mutations in melanoma confer a worse prognosis with CNS diseases often serving as a terminal event. In this study we: 1] Compared the incidence of metastatic disease to the brain and the time to development of CNS metastases in patients with BRAFV600E mutations vs. wtBRAF, 2] Attempted to determine differences in outcome between patients with surgery and/or radiation therapy, and 3] assessed the effect of BRAF inhibitor therapy on the incidence of brain metastases. Methods Retrospective review of all melanoma patients who