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Edward D. Hall

probably required to achieve a membrane concentration sufficient to protect the susceptible polyunsaturated fatty acids and cholesterol from attack by free radicals, such as superoxide, hydroxyl radical, and singlet oxygen. This antioxidant capability of methylprednisolone has been observed in ovolecithin liposomes, 27 cat spinal cord homogenates, 19 and rat brain synaptosomes. 3 In the latter instance, the optimal concentration of methylprednisolone needed to attenuate in vitro peroxidation is 100 µ M, which is close to the concentration found in cat spinal cord

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Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na+ + K+)-ATPase activity

Dose-response analysis during 1st hour after contusion injury in the cat

Edward D. Hall and J. Mark Braughler

peroxidation, the demonstration of a decrease by methylprednisolone in the in vitro formation of lipid peroxides in spinal cord homogenates 18 shows an additional glucocorticoid action on lipid peroxidation per se . This view is further supported by the observation that methylprednisolone incorporation decreases lipid peroxidation in ultraviolet-irradiated liposomes, possibly via an antioxidant effect of the glucocorticoid. 31 One of the initial and functionally significant consequences of tissue lipid peroxidation is a decline in the activities of various membrane

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Edward D. Hall and Daniel L. Wolf

: Arachidonic acid and lipid metabolism following spinal cord trauma. Soc Neurosci Abst 10 : 998 , 1984 (Abstract) Saunders RD, Anderson DK, Horrocks LA: Arachidonic acid and lipid metabolism following spinal cord trauma. Soc Neurosci Abst 10: 998, 1984 (Abstract) 50. Seligman ML , Mitamura J , Shera N , et al : Corticosteroid (methylprednisolone) modulation of photoperoxidation by ultraviolet light in liposomes. Photochem Photobiol 29 : 549 – 558 , 1979 Seligman ML, Mitamura J, Shera N, et al

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Edward D. Hall, Daniel L. Wolf and J. Mark Braughler

a direct membrane action) may be responsible for the therapeutic effect. Indeed, high concentrations (0.5 mM or higher) of naloxone have been shown to inhibit iron-catalyzed peroxidation in artificial liposomes. 30 Thus, this indirect evidence concerning possible lipid-protecting actions of naloxone in relation to CNS injury further suggests a role of lipid peroxidation in the evolution of posttraumatic CNS ischemia and tissue destruction. In summary, a single large (30-mg/kg) intravenous dose of MPSS can significantly prevent the development of posttraumatic

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J. Mark Braughler, Edward D. Hall, Eugene D. Means, Thomas R. Waters and Douglas K. Anderson

compression trauma to the feline spinal cord. J Neurosurg 55: 200–208, 1981 23. Seligman ML , Mitamura J , Shera N , et al : Corticosteroid (methylprednisolone) modulation of photoperoxidation by ultraviolent light in liposomes. Photochem Photobiol 29 : 549 – 558 , 1979 Seligman ML, Mitamura J, Shera N, et al: Corticosteroid (methylprednisolone) modulation of photoperoxidation by ultraviolent light in liposomes. Photochem Photobiol 29: 549–558, 1979 24. Young W , Flamm ES : Effect of high

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Douglas K. Anderson, J. Mark Braughler, Edward D. Hall, Thomas R. Waters, John M. McCall and Eugene D. Means

species and radical products in cat spinal cord. Ann NY Acad Sci 222: 1102–1111, 1973 43. Seligman ML , Mitamura J , Shera N , et al : Corticosteroid (methylprednisolone) modulation of photoperoxidation by ultraviolet light in liposomes. Photochem Photobiol 29 : 549 – 558 , 1979 Seligman ML, Mitamura J, Shera N, et al: Corticosteroid (methylprednisolone) modulation of photoperoxidation by ultraviolet light in liposomes. Photochem Photobiol 29: 549–558, 1979 44. Travis MA , Hall ED