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, with >90% of cells confirmed to have EC identity on flow cytometry (CD45-CD31+). These cells were also significantly enriched for EC-related genes such as Cdh5, Icam2, Nos3 and Pecam1. Microarray results will provide a list of genes that are significantly upregulated or downregulated in BECs after SAH, requiring further validation studies. Conclusion: BBB disruption is greater at 24h than at 48h in an experimental SAH model. This study is the first to provide whole genome expression profiling of freshly-isolated BECs derived from an SAH animal model. Thereby

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extracellular water content of brain for improved MR imaging. Preclinical safety testing in a large brain, animal model is now complete, and a clinical trial is being designed to assess the feasibility in patients with movement disorders. J Neurosurg Journal of Neurosurgery JNS 0022-3085 1933-0693 American Association of Neurological Surgeons 2015.6.JNS.AANS2014ABSTRACTS Philip L. Gildenberg Resident Award 639. Brain Computer Interface Technology for Patients Suffering Disorder of Consciousness Robert Prueckl , (Schiedlberg