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John H. Sampson, James E. Herndon II, Allan H. Friedman and Amy P. Abernethy

and Quality in detailed registries like SEER will drive observational research on a national scale, and local investments in high-quality databases and registries relevant to neurosurgery will ensure we have a place at the table. Newer analytic techniques are on the horizon to help make sense of accumulating data; NIH, the Agency for Healthcare Research and Quality, and other organizations are investing in mathematical modeling, new artificial intelligence approaches, and a growing comparative effectiveness research workforce that is prepared to analyze