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Malte Ottenhausen, Imithri Bodhinayake, Alexander I. Evins, Matei Banu, John A. Boockvar and Antonio Bernardo

In this article the authors discuss the development of neurosurgical approaches and the advances in science and technology that influenced this development throughout history. They provide a broad overview of this interesting topic from the first attempts of trephination by ancient cultures to the work of the pioneers of neurosurgery and the introduction of microsurgery.