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Michael J. Schlosser, Marie Luby, Dennis D. Spencer, Issam A. Awad and Gregory McCarthy

language areas identified by functional magnetic resonance imaging. J Neurosci 17: 353–362, 1997 5. Binder JR , Swanson SJ , Hammeke TA , et al : Determination of language dominance using functional MR imaging: a comparison with the Wada test. Neurology 46 : 978 – 984 , 1996 Binder JR, Swanson SJ, Hammeke TA, et al: Determination of language dominance using functional MR imaging: a comparison with the Wada test. Neurology 46: 978–984, 1996 6. Bookheimer SY : Functional MRI applications in clinical epilepsy. Neuroimage 4 : S139 – S146 , 1996

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Alexandre C. Carpentier, R. Todd Constable, Michael J. Schlosser, Alain de Lotbinière, Joseph M. Piepmeier, Dennis D. Spencer and Issam A. Awad

analysis of early somatosensory evoked potentials and three-dimensional magnetic resonance imaging. J Neurosurg 80: 849–856, 1994 4. Cao Y , D'Olhaberriague L , Vikingstad EM , et al : Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 29 : 112 – 122 , 1998 Cao Y, D'Olhaberriague L, Vikingstad EM, et al: Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 29: 112–122, 1998 5. Cao

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Peter G. Campbell, Pascal Jabbour, Sanjay Yadla and Issam A. Awad

, McKhann GM II : “Epilepsy surgery” versus lesionectomy in patients with seizures secondary to cavernous malformations . Clin Neurosurg 55 : 101 – 107 , 2008 25 Krings T , Reinges MH , Erberich S , Kemeny S , Rohde V , Spetzger U , : Functional MRI for presurgical planning: problems, artefacts, and solution strategies . J Neurol Neurosurg Psychiatry 70 : 749 – 760 , 2001 26 Labauge P , Brunereau L , Lévy C , Laberge S , Houtteville JP : The natural history of familial cerebral cavernomas: a retrospective MRI study of 40

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Romuald Girard, Maged D. Fam, Hussein A. Zeineddine, Huan Tan, Abdul Ghani Mikati, Changbin Shi, Michael Jesselson, Robert Shenkar, Meijing Wu, Ying Cao, Nicholas Hobson, Henrik B. W. Larsson, Gregory A. Christoforidis and Issam A. Awad

and reimbursement factors. Ultimately, as with many novel techniques, the generalizability to clinical settings will be dictated by the team's interests/expertise, volume of cases, etc. This would be similar to MR spectroscopy and functional MRI, which require a similar level of image acquisition and processing sophistication, and that ultimately have found their roles at large specialized clinical centers. Conclusions This is the largest study of its kind, and the first report on prospectively enrolled, longitudinally assessed cases with CCM in correlation with