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  • Journal of Neurosurgery x
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Alexander K. Powers, Matthew T. Neal, Louis C. Argenta, John A. Wilson, Anthony J. DeFranzo and Stephen B. Tatter

treated with VAC compared with previously published results. Expedited colonization of a synthetic matrix by host cells in the case of complex cranial wounds with loss of dura is critical to restore the competency of the CSF compartment and eliminate infection. One concern about using VAC on open cranial wounds is the creation of a CSF fistula or CSF overdrainage. In all of our cases, we attempted to compartmentalize the CSF space by closing the dura primarily or by suturing an autologous graft or synthetic dural matrix to dural margins. In cases in which dural