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Neal F. Kassell, E. Clarke Haley Jr., Carolyn Apperson-Hansen, Wayne M. Alves and Participants

anteroposterior and lateral films from baseline and follow-up angiograms were copied and sent to the Central Registry at the University of Virginia where they were interpreted by a single blinded investigator. The severity of vasospasm was graded as mild, moderate, or severe, as previously described. 8 Additionally, transcranial Doppler ultrasonography was performed at least every other day from patient entry until Day 14. The maximum mean blood flow velocity from both the right and left middle cerebral arteries was recorded. Overall outcome was assessed 3 months after SAH

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E. Clarke Haley Jr., Neal F. Kassell, Carolyn Apperson-Hansen, Marie H. Maile, Wayne M. Alves and Participants

was graded as mild, moderate, or severe, as previously described. 8 Additionally, TCD ultrasonography was performed at least every other day from patient entry until Day 14 post-SAH. The maximum mean blood flow velocity from both the right and left middle cerebral arteries was recorded. Overall outcome was assessed at 3 months after SAH using the GOS. 11 Neurological outcome was evaluated using the NIH Stroke Scale. 1, 15 A follow-up CT scan of the head was obtained at 3 months and sent to the Central Registry for blinded interpretation and measurement of

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Giuseppe Lanzino, Neal F. Kassell, Nicholas W. C. Dorsch, Alberto Pasqualin, Lennart Brandt, Peter Schmiedek, Laura L. Truskowski, Wayne M. Alves and the Participants

worsening during the treatment period unrelated to vasospasm was also monitored. When such worsening was recognized, the investigators were required to designate a primary cause and the treatment initiated. Use of cerebral angioplasty for treatment of symptomatic vasospasm was allowed, but subsequent data on arterial narrowing, obtained using angiography or TCD ultrasonography, were censored in these patients. Transcranial Doppler ultrasonography was performed at least every other day from patient entry until Day 14. The maximum mean blood flow velocity from both right