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  • By Author: Abeygunasekera, Manil x
  • By Author: Link, Michael J. x
  • By Author: Aletich, Victor x
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some patients showed viral protein, DNA, and RNA including CD, but with viral genes only detected in limited amounts and not in all samples (up to 2000 DNA copies/μg tissue). MRI immediately after injecting Toca 511 plus gadolinium showed imprecise delivery. Therefore, realtime MRI-guided CED was implemented. In 7 patients at a single center (average tumor volume = 10.5 cm3, range=2.6–25.0 cm3) 12–70% of tumor volume (mean=45%) was infused. A 14-gauge cannula allowed flow rates up to 50 microL/min without reflux, and 3.1 mL was delivered to 1–3 targets with improved