Search Results

You are looking at 1 - 10 of 962 items for :

  • "traumatic brain injury" x
  • Journal of Neurosurgery x
  • Refine by Access: all x
Clear All
Restricted access

Samuel S. Shin, C. Edward Dixon, David O. Okonkwo, and R. Mark Richardson

T here are multiple therapy modalities for attenuating neurological disabilities in traumatic brain injury (TBI) patients, including occupational, physical, and cognitive rehabilitation, but there is a critical need for more effective therapies, especially pharmacological or surgical treatments. The pathophysiology of TBI is complex and includes inflammation, oxidative stress, apoptosis, excitotoxicity, and mitochondrial dysfunction. After almost a century of translational science, there has yet to be a successful Phase III clinical trial investigating a

Restricted access

Ryan S. Kitagawa, Robert M. Van Haren, Shoji Yokobori, David Cohen, Samuel R. Beckerman, Faiz Ahmad, and M. Ross Bullock

LE : Traumatic aortic injury: computerized tomographic findings at presentation and after conservative therapy . J Comput Assist Tomogr 34 : 388 – 394 , 2010 2 Andrews PJ , Sleeman DH , Statham PF , McQuatt A , Corruble V , Jones PA , : Predicting recovery in patients suffering from traumatic brain injury by using admission variables and physiological data: a comparison between decision tree analysis and logistic regression . J Neurosurg 97 : 326 – 336 , 2002 3 Arthurs ZM , Starnes BW , Sohn VY , Singh N , Martin MJ

Restricted access

Bon H. Verweij, J. Paul Muizelaar, Federico C. Vinas, Patti L. Peterson, Ye Xiong, and Chuan P. Lee

–497, 1982 2. Bergsneider M , Hovda DA , Shalmon E , et al : Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 86 : 241 – 251 , 1997 Bergsneider M, Hovda DA, Shalmon E, et al: Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 86: 241–251, 1997 3. Berman RF , Verweij BH , Muizelaar JP : Neurobehavioral protection by the neuronal calcium channel blocker Ziconotide in a model of traumatic diffuse brain

Restricted access

Brian J. Zink and Paul J. Feustel

E thanol (EtOH) consumption leads to an increased risk of accidents and trauma; 13, 25 studies in emergency department patients have shown that up to 50% of brain-injured adults have consumed EtOH prior to suffering traumatic brain injury (TBI). 4, 8, 17, 31, 32 A number of animal studies, each using a different model and species, has found that EtOH worsens brain injury and neurological outcome and increases mortality following brain injury. 1, 11, 12, 22 These investigations have focused primarily on neuropathological lesions and mortality and have not

Restricted access

Michael F. Stiefel, Joshua D. Udoetuk, Alejandro M. Spiotta, Vicente H. Gracias, Aaron Goldberg, Eileen Maloney-Wilensky, Stephanie Bloom, and Peter D. Le Roux

: Monitoring of brain tissue PO2 in traumatic brain injury: effect of cerebral hypoxia on outcome . Acta Neurochir Suppl 71 : 153 – 156 , 1998 6 Bishop MH , Shoemaker WC , Appel PL , Meade P , Ordog GJ , Wasserberger J , : Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma . J Trauma 38 : 780 – 787 , 1995 7 Bouma GJ , Muizelaar JP , Choi SC , Newlon PG , Young HF : Cerebral circulation and metabolism after severe traumatic brain

Restricted access

Robert G. Whitmore, Jayesh P. Thawani, M. Sean Grady, Joshua M. Levine, Matthew R. Sanborn, and Sherman C. Stein

. 6 However, we have corrected the estimates of Faul et al., 6 which were based on average costs for all hospitalized traumatic brain injury (TBI) patients, not just for those with severe TBI. We used a formula that relied on the relative cost of a day in the ICU being approximately 3 times as much as care on a medical-surgical floor. 9 Hence, in contrast to the calculations of Faul et al., in our calculations, hospitalization for the aggressive-treatment group costs considerably more than that for the routine-care group. Average ICU and hospital stays for the

Restricted access

Ronald L. Hayes, Bruce G. Lyeth, Larry W. Jenkins, Richard Zimmerman, Tracy K. McIntosh, Guy L. Clifton, and Harold F. Young

P revious research has indicated that traumatic brain injury (TBI) increases levels of endogenous opioids. Naloxone, a nonspecific opioid antagonist, significantly reverses the hypotension and reduction in pulse pressure following fluid-percussion injury in cats. 26 There are also recent clinical reports of increased µ -endorphin levels in the cerebrospinal fluid of head-injured patients. 80 Other laboratory studies have indicated that dynorphin A-immunoreactivity (but not leucine-enkephalin or µ -endorphin immunoreactivity) increased in the brain regions

Restricted access

Tobias Clausen, Ahmad Khaldi, Alois Zauner, Michael Reinert, Egon Doppenberg, Matthias Menzel, Jens Soukup, Oscar Luis Alves, and M. Ross Bullock

, Grande PO, Nordstrom CH: A new therapy of posttrauma brain oedema based on haemodynamic principles for brain volume regulation. Intensive Care Med 20: 260–267, 1994 5. Bergsneider M , Hovda DA , Shalmon E , Kelly DF , Vespa PM , Martin NA , et al : Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 86 : 241 – 251 , 1997 Bergsneider M, Hovda DA, Shalmon E, Kelly DF, Vespa PM, Martin NA, et al: Cerebral hyperglycolysis following

Restricted access

Matthew A. Warner, Terence O'Keeffe, Premal Bhavsar, Rashmi Shringer, Carol Moore, Caryn Harper, Christopher J. Madden, Ravi Sarode, Larry M. Gentilello, and Ramon Diaz-Arrastia

Alvarez M , Nava JM , Rué M , Quintana S : Mortality prediction in head trauma patients: performance of Glasgow Coma Score and general severity systems . Crit Care Med 26 : 142 – 148 , 1998 2 Bardt TF , Unterberg AW , Härtl R , Kiening KL , Schneider GH , Lanksch WR : Monitoring of brain tissue PO2 in traumatic brain injury: effect of cerebral hypoxia on outcome . Acta Neurochir Suppl 71 : 153 – 156 , 1998 3 Carlson AP , Schermer CR , Lu SW : Retrospective evaluation of anemia and transfusion in traumatic brain injury

Restricted access

Matthew T. Harting, Fernando Jimenez, Hasan Xue, Uwe M. Fischer, James Baumgartner, Pramod K. Dash, and Charles S. Cox Jr.

C ell therapy has garnered significant interest as a treatment strategy for a wide range of diseases over the last decade. Heart disease, peripheral vascular disease, bone disease, cancer, hepatic disease, and neurological disease have all been the focus of promising cell therapy breakthroughs. 7 , 15 , 23 , 24 , 34 , 40 , 48 Traumatic brain injury is one area in which positive preclinical evidence has led to the initiation of early clinical trials ( www.clinicaltrials.gov ). Although cell therapy has been hailed as one of the next frontiers in modern