Search Results

You are looking at 1 - 10 of 249 items for :

  • "medically refractory epilepsy" x
  • All content x
Clear All
Full access

David E. Connor Jr., Menarvia Nixon, Anil Nanda, and Bharat Guthikonda

indicated for “adults and adolescents over 12 years of age with medically intractable partial seizures who are not candidates for potentially curative surgical resections, such as lesionectomies or mesial temporal lobectomies.” 12 We propose, utilizing evidence-based classification and guidelines, to perform a review of the currently available literature on the application of VNS in patients with medically refractory epilepsy. Methods An English-language literature search on the use of VNS for the treatment of medically refractory epilepsy was performed utilizing

Free access

Armin Mortazavi, Ross-Jordon S. Elliott, Tiffany N. Phan, John Schreiber, William D. Gaillard, and Chima O. Oluigbo

particular focus on technical aspects and outcomes. Methods Study Description and Data Collection After Children’s National Hospital IRB approval, a single-center retrospective study reviewed pediatric patients who underwent RNS System implantation (n = 5). Each case was discussed at a multidisciplinary meeting, and the RNS System was considered a treatment option only after concluding that the patient had significant medically refractory epilepsy (MRE) involving eloquent cortex. The following variables were collected: age, sex, handedness, age at epilepsy

Restricted access

Gregory W. Albert, Nader S. Dahdaleh, Chandan Reddy, Daniel R. Hansen, Timothy W. Vogel, Hiroto Kawasaki, and Matthew A. Howard III

extraaxial fluid collection. The current review was similarly organized to study correlations between head CT findings and clinically significant extraaxial hematoma formation in a larger series of patients all of whom underwent head CT on postoperative Day 1. Our series included 46 patients who underwent intracranial monitoring for medically refractory epilepsy. We examined each CT scan for the thickness of the extraaxial fluid collection, presence of other intracranial hemorrhages, degree of midline shift, and presence of ventricular asymmetry. We then evaluated how

Full access

Panagiotis Kerezoudis, Brandon McCutcheon, Meghan E. Murphy, Kenan R. Rajjoub, Daniel Ubl, Elizabeth B. Habermann, Gregory Worrell, Mohamad Bydon, and Jamie J. Van Gompel

A pproximately one-third of the 3 million people with epilepsy in the US continue to have seizures despite taking antiseizure medications (ASMs). 5 Once medically intractable seizures are established (failure of 2 ASMs at reasonable dosing to control seizures), patients are evaluated for surgical intervention. Surgical therapy represents an important yet underutilized treatment in patients with medically refractory epilepsy, despite the existence of Class I evidence advocating the efficacy and safety of resective surgery in a selected population. 6 , 8 , 21

Restricted access

Saadi Ghatan, Patricia McGoldrick, Christina Palmese, Maite La Vega-Talbott, Harriet Kang, Malgosia A. Kokoszka, Robert R. Goodman, and Steven M. Wolf

cortical development and benign tumors, very little has been reported focused on stroke or other vasculogenic causes in children. 7 , 11 , 28 In this paper, to demonstrate the safety and efficacy of epilepsy surgery in this population, we describe our series of patients who experienced medically refractory epilepsy due to perinatal infarction and/or hemorrhage, and underwent surgery. Methods Record Review A confidential database of more than 1500 patients with epilepsy treated at the Comprehensive Epilepsy Center of Beth Israel Medical Center and St. Luke

Restricted access

Michael A. Murphy, Terence J. O'Brien, Kevin Morris, and Mark J. Cook

changes. Conclusions In this paper, we describe a series of patients who underwent MMIGS for medically refractory epilepsy and achieved seizure-free results substantially better than those previously reported in patients with nonlesional epilepsy. The high rates of excellent and favorable outcomes in this series indicate that the incorporation of additional imaging modalities, in particular functional modalities, into an IGSS may allow for improved seizure outcome and potential freedom from seizures in patients with no discrete structural pathological feature

Full access

Thomas L. Ellis and Andrew Stevens

E pilepsy is a common chronic neurological disorder that affects 0.5–1% of the population. 30 More than one-third of all patients with epilepsy have incompletely controlled seizures or debilitating medication side effects in spite of optimal medical management. 40 , 65 , 68 Medically refractory epilepsy is associated with injury and death, psychosocial dysfunction, and significant cognitive impairment. 9 Treatment options for these patients include new AEDs, which may lead to seizure freedom in 7% of patients, 22 and resection, which is associated with

Restricted access

Doris D. Wang, Barlas Benkli, Kurtis I. Auguste, Paul A. Garcia, Joseph Sullivan, A. James Barkovich, Edward F. Chang, and Tarik Tihan

C ortical malformations and inflammatory encephalopathy are among the common etiologies for medically refractory epilepsy in children. On rare occasions, lesions can affect an entire cerebral hemisphere while sparing the other, and 2 processes that can manifest in this manner are hemimegalencephaly (HME) and Rasmussen's encephalitis (RE). Hemimegalencephaly is characterized by unilateral enlargement of one of the cerebral hemispheres from disturbances during corticogenesis that manifest as refractory epilepsy during infancy and early childhood. 7 HME

Free access

Stephen C. Harward and Derek G. Southwell

E pilepsy , a condition affecting approximately 1% of the population, is refractory to medical therapies in nearly 30% of cases. 8 , 13 Surgical treatments for epilepsy, which include brain resection, laser ablation, and neurostimulation, can be effective treatment adjuncts for medically refractory epilepsy. However, due to limiting factors such as stringent criteria for patient selection, significant postoperative morbidity, and suboptimal seizure outcomes, current surgical modalities remain inadequate for fully treating the diverse forms of medically

Restricted access

Anthony T. Lee, John F. Burke, Pranathi Chunduru, Annette M. Molinaro, Robert Knowlton, and Edward F. Chang

E pilepsy now affects approximately 3 million adults and 470,000 children in the US (1.2% of the US population), and only 44% of those taking antiepileptic drugs (AEDs) report having adequate seizure control. 43 Despite clear evidence of the benefit of surgery for medically refractory epilepsy, 7 and the recommendations from the American Academy of Neurology to refer patients with drug-resistant seizures to an epilepsy center, 13 surgery remains underutilized. 14 , 21 , 25 Although temporal lobe epilepsy (TLE) is the most common focal epilepsy and the most