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Daniel Jeanmonod, Beat Werner, Anne Morel, Lars Michels, Eyal Zadicario, Gilat Schiff, and Ernst Martin

landmark clinical study 23 examined the feasibility and initial technical results of tcMRgFUS and showed for the first time in 3 patients that it is possible to focus the ultrasound beam through the intact skull into the brain and to visualize internal heating at the focal point and on the brain surface by using MR imaging temperature mapping. These findings constitute a significant step forward in establishing an entirely noninvasive alternative therapy to surgery for brain disorders. Based on our long-term clinical experience in functional neurosurgery for