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Nicholas M. Wetjen, W. Richard Marsh, Fredric B. Meyer, Gregory D. Cascino, Elson So, Jeffrey W. Britton, S. Matthew Stead, and Gregory A. Worrell

P artial epilepsy represents the most common type of intractable epilepsy, and partial seizures originating from neocortex are notoriously difficult to localize and treat. 11 , 44 Presently, treatment options for patients with medically refractory epilepsy are limited to implantation of a vagus nerve stimulator, which has similar efficacy to medical therapy. 13 Epilepsy surgery has the best chance of producing a cure, that is, complete seizure freedom, but it is a viable option only if the brain region generating seizures can be accurately localized and