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Robert D. Brown JR., John Huston III, Richard Hornung, DR.P.H., Tatiana Foroud, David F. Kallmes, Dawn Kleindorfer, Irene Meissner, Daniel Woo, Laura Sauerbeck, Joseph Broderick, and for the Familial Intracranial Aneurysm (FIA) Investigators

I ntracranial saccular aneurysms are acquired lesions, accounting for ~ 80% of all nontraumatic SAHs. Several uncommon heritable disorders are associated with brain aneurysms, including autosomal-dominant polycystic kidney disease, 3 Marfan syndrome, 17 Ehlers–Danlos syndrome Type IV, 4 hereditary hemorrhagic telangiectasia, 11 pseudoxanthoma elasticum, multiple endocrine neoplasia Type I, and neurofibromatosis Type 1. 16 Outside of these rare heritable disorders, population-based 8 , 18 and nonpopulation-based 10 , 12–14 data suggest that there is

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Jason Mackey, Robert D. Brown Jr., Charles J. Moomaw, Laura Sauerbeck, Richard Hornung, Dheeraj Gandhi, Daniel Woo, Dawn Kleindorfer, Matthew L. Flaherty, Irene Meissner, Craig Anderson, E. Sander Connolly, Guy Rouleau, David F. Kallmes, James Torner, John Huston III, and Joseph P. Broderick

polycystic kidney disease, Ehlers-Danlos syndrome, Marfan syndrome, fibromuscular dysplasia, or moyamoya syndrome are excluded. Patients are also excluded if informed consent cannot be obtained. A verification committee, consisting of study neurologists from the University of Cincinnati and the Mayo Clinic, reviews all medical records. Two study neurologists independently review the records, and any discrepancy is adjudicated by a third neurologist. For patients who undergo FIA study imaging, two neuroradiologists at the Study Imaging Center at Mayo Clinic in Rochester