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Robert D. Brown JR., John Huston III, Richard Hornung, DR.P.H., Tatiana Foroud, David F. Kallmes, Dawn Kleindorfer, Irene Meissner, Daniel Woo, Laura Sauerbeck, Joseph Broderick, and for the Familial Intracranial Aneurysm (FIA) Investigators

I ntracranial saccular aneurysms are acquired lesions, accounting for ~ 80% of all nontraumatic SAHs. Several uncommon heritable disorders are associated with brain aneurysms, including autosomal-dominant polycystic kidney disease, 3 Marfan syndrome, 17 Ehlers–Danlos syndrome Type IV, 4 hereditary hemorrhagic telangiectasia, 11 pseudoxanthoma elasticum, multiple endocrine neoplasia Type I, and neurofibromatosis Type 1. 16 Outside of these rare heritable disorders, population-based 8 , 18 and nonpopulation-based 10 , 12–14 data suggest that there is