Search Results

You are looking at 1 - 10 of 22 items for :

  • "traumatic brain injury" x
  • Refine by Access: all x
  • By Author: Xiong, Ye x
Clear All
Restricted access

Bon H. Verweij, J. Paul Muizelaar, Federico C. Vinas, Patti L. Peterson, Ye Xiong, and Chuan P. Lee

–497, 1982 2. Bergsneider M , Hovda DA , Shalmon E , et al : Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 86 : 241 – 251 , 1997 Bergsneider M, Hovda DA, Shalmon E, et al: Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 86: 241–251, 1997 3. Berman RF , Verweij BH , Muizelaar JP : Neurobehavioral protection by the neuronal calcium channel blocker Ziconotide in a model of traumatic diffuse brain

Restricted access

Ye Xiong, Asim Mahmood, Yuling Meng, Yanlu Zhang, Zheng Gang Zhang, Daniel C. Morris, and Michael Chopp

. Velocity was measured with a linear velocity displacement transducer. Experimental Groups and Treatment Young adult male Wistar rats were divided into 3 groups: 1) sham group (6 rats); 2) TBI + saline group (9 rats); and 3) TBI + Tβ 4 group (10 rats). Traumatic brain injury was induced by controlled cortical impact over the left parietal cortex. Sham rats underwent surgery without injury. Thymosin β 4 (RegeneRx Biopharmaceuticals, Inc.) dissolved in saline at a dose of 6 mg/kg was administered intraperitoneally starting at Day 1 after injury, and then it was

Restricted access

Changsheng Qu, Ye Xiong, Asim Mahmood, David L. Kaplan, Anton Goussev, Ruizhuo Ning, and Michael Chopp

: neurotrophins and functional recovery . Neurology 59 : 514 – 523 , 2002 16 Liu Z , Li Y , Qu R , Shen L , Gao Q , Zhang X , : Axonal sprouting into the denervated spinal cord and synaptic and postsynaptic protein expression in the spinal cord after transplantation of bone marrow stromal cell in stroke rats . Brain Res 1149 : 172 – 180 , 2007 17 Lu D , Li Y , Mahmood A , Wang L , Rafiq T , Chopp M : Neural and marrow-derived stromal cell sphere transplantation in a rat model of traumatic brain injury . J Neurosurg 97 : 935

Restricted access

Ye Xiong, Dunyue Lu, Changsheng Qu, Anton Goussev, Timothy Schallert, Asim Mahmood, and Michael Chopp

anesthetized intraperitoneally with a 400-mg/kg body weight dose of chloral hydrate. Body temperature was maintained at 37°C by using a circulating water heating pad. Traumatic brain injury was delivered as previously described 37 , 54 , 65 , 66 with minor modifications. Each animal was placed in a stereotactic frame. A 4-mm-diameter craniotomy was performed over the left parietal cortex adjacent to the central suture, midway between lambda and bregma. The dura mater was kept intact over the cortex. Injury was induced by impacting the left cortex (ipsilateral cortex) with a

Full access

Yanlu Zhang, Zheng Gang Zhang, Michael Chopp, Yuling Meng, Li Zhang, Asim Mahmood, and Ye Xiong

, Shinozuka K , Ishikawa H , Sanberg PR , Sanchez-Ramos J , : Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury . PLoS One 9 : e90953 , 2014 10.1371/journal.pone.0090953 2 Adams RA , Schachtrup C , Davalos D , Tsigelny I , Akassoglou K : Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis . Curr Med Chem 14 : 2925 – 2936

Full access

Yanlu Zhang, Michael Chopp, Yuling Meng, Zheng Gang Zhang, Edith Doppler, Stefan Winter, Timothy Schallert, Asim Mahmood, and Ye Xiong

: injury severity predicts motor and cognitive performance after trauma . Neurol Res 21 : 742 – 754 , 1999 5 Bernal-Mondragón C , Rivas-Arancibia S , Kendrick KM , Guevara-Guzmán R : Estradiol prevents olfactory dysfunction induced by A-β 25–35 injection in hippocampus . BMC Neurosci 14 : 104 , 2013 6 Bornstein N , Poon WS : Accelerated recovery from acute brain injuries: clinical efficacy of neurotrophic treatment in stroke and traumatic brain injuries . Drugs Today (Barc) 48 Suppl A : 43 – 61 , 2012 7 Bye N , Carron S , Han X

Restricted access

Ye Xiong, Yanlu Zhang, Asim Mahmood, Yuling Meng, Zheng Gang Zhang, Daniel C. Morris, and Michael Chopp

6-mm–diameter tip at the rate of 4 m/second and 2.5 mm of compression. Velocity was measured with a linear velocity displacement transducer. Experimental Groups and Treatment Traumatic brain injury was induced by CCI over the left parietal cortex. Young adult male Wistar rats with TBI were randomly divided into 3 groups: 1) saline group (n = 7); 2) 6 mg/kg Tβ4 group (n = 8); and 3) 30 mg/kg Tβ4 group (n = 8). An additional group of 6 rats underwent surgery but were not subjected to TBI (sham-injury group). Our previous studies showed that 6–8 animals per

Restricted access

Hongtao Wu, Asim Mahmood, Dunyue Lu, Hao Jiang, Ye Xiong, Dong Zhou, and Michael Chopp

T raumatic brain injury is a leading cause of serious, long-term disability worldwide. Widely distributed neuronal damage has been well documented in the cerebral cortex, hippocampus, and dentate gyrus of the brain during the first few days after experimental TBI in rats. 13 Traumatic brain injury results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis, which plays a key role in the process of neuroinflammation. 8 Although its role after neuronal injury is still controversial, reactive astrogliosis is

Restricted access

Yuling Meng, Ye Xiong, Asim Mahmood, Yanlu Zhang, Changsheng Qu, and Michael Chopp

Ford Health System. Traumatic Brain Injury Model A CCI model of TBI in the rat was used for the present study. 16 , 35 Young adult male Wistar rats (313.4 ± 8.9 g) were anesthetized intraperitoneally with chloral hydrate (350 mg/kg body weight). Rectal temperature was maintained at 37°C using a feedback-regulated water-heating pad. A CCI device was used to induce injury. Rats were placed in a stereotactic frame. Two 10-mm-diameter craniotomies were performed adjacent to the central suture, midway between lambda and bregma. The second craniotomy allowed for

Restricted access

Hongtao Wu, Dunyue Lu, Hao Jiang, Ye Xiong, Changsheng Qu, Bo Li, Asim Mahmood, Dong Zhou, and Michael Chopp

, Wang Y , Wang L , Jiang H , : Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke . Ann Neurol 53 : 743 – 751 , 2003 7 Clark RS , Kochanek PM , Watkins SC , Chen M , Dixon CE , Seidberg NA , : Caspase-3 mediated neuronal death after traumatic brain injury in rats . J Neurochem 74 : 740 – 753 , 2000 8 Dijkers PF , Medema RH , Lammers JW , Koenderman L , Coffer PJ : Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHRL1 . Curr Biol