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Hariyadarshi Pannu, Dong H. Kim, C. Robyn Seaman, Grace Van Ginhoven, Sanjay Shete, and Dianna M. Milewicz

the biological basis of the disease is beneficial to the development of technologies that aid in improving diagnosis and risk assessment as well as in improving prognosis by identifying aneurysms prone to rupture and by defining pathways for therapeutic drug-based intervention strategies. Approximately 5% of IAs are associated with heritable connective tissue disorders such as Ehlers—Danlos syndrome Type IV, Marfan syndrome, autosomal dominant polycystic kidney disease, and neurofibromatosis Type 1. 22 Between 5 and 20% of cases have been reported to occur in

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Hariyadarshi Pannu, Dong H. Kim, Dongchuan Guo, Terri M. King, Grace Van Ginhoven, Toinette Chin, Katherine Chang, Yuhua Qi, Sanjay Shete, and Dianna M. Milewicz

have identified several chromosomal regions, including regions on 1p, 2p, 7q, and 19q, that are linked to nonsyndromic familial intracranial aneurysms. 13 , 14 , 21 , 27 In addition, intracranial aneurysms have been noted to occur in association with certain syndromes (such as Ehlers–Danlos syndrome Type IV, polycystic kidney disease, neurofibromatosis Type 1, alpha 1-antitrypsin deficiency, and familial thoracic aortic aneurysms and dissections). A subset of these intracranial aneurysms has been reported to be caused by defects in genes that are involved in