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Panagiotis Kerezoudis, Sanjeet S. Grewal, Matthew Stead, Brian Nils Lundstrom, Jeffrey W. Britton, Cheolsu Shin, Gregory D. Cascino, Benjamin H. Brinkmann, Gregory A. Worrell, and Jamie J. Van Gompel

cortical and subcortical brain regions, including the thalamus, the cerebellum, and the hippocampus, have been selected as neurostimulation targets utilizing either duty cycle 14 or responsive stimulation paradigms. 3 Despite their demonstrated efficacy in randomized controlled trials, currently approved stimulation approaches do not often result in seizure-free outcomes. 3 , 14 Chronic subthreshold cortical stimulation (CSCS) might represent a more effective option. Currently available responsive neurostimulation device detection algorithms 3 use a low spectral