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Hariyadarshi Pannu, Dong H. Kim, C. Robyn Seaman, Grace Van Ginhoven, Sanjay Shete, and Dianna M. Milewicz

the biological basis of the disease is beneficial to the development of technologies that aid in improving diagnosis and risk assessment as well as in improving prognosis by identifying aneurysms prone to rupture and by defining pathways for therapeutic drug-based intervention strategies. Approximately 5% of IAs are associated with heritable connective tissue disorders such as Ehlers—Danlos syndrome Type IV, Marfan syndrome, autosomal dominant polycystic kidney disease, and neurofibromatosis Type 1. 22 Between 5 and 20% of cases have been reported to occur in