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Andrés M. Lozano and Richard Leblanc

vascular degeneration added to congenital predisposition may be important in the formation of aneurysms. The role of inheritance in the genesis of cerebral aneurysms is well established for certain disorders such as Type IV Ehlers-Danlos syndrome, Marfan's syndrome, pseudoxanthoma elasticum, and polycystic kidney disease. 22 In addition, a large number of familial cases of cerebral aneurysms not associated with a recognized inherited disorder have been reported. It is therefore of interest to compare the demographic and pathological features of familial cerebral

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Richard Leblanc, Andrés M. Lozano, Michel van der Rest, and Ronald David Guttmann

demonstration of such a deficiency in patients with Ehlers-Danlos syndrome type IV (a genetically determined condition) has suggested to some that a minor deficiency in type III collagen may be important in the development of cerebral aneurysms. 4–6 This deficiency could result from a defect in the type III collagen gene or in its expression. Such a genetically determined deficiency would be expected to occur in clearcut cases of familial cerebral aneurysms. The demonstration of such a deficiency would strongly support the concept of a genetic etiology of cerebral aneurysms