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Rosa Q. So, Vibhor Krishna, Nicolas Kon Kam King, Huijuan Yang, Zhuo Zhang, Francesco Sammartino, Andres M. Lozano, Richard A. Wennberg, and Cuntai Guan

anterior nucleus thalamic deep brain stimulation (DBS) dates back to the 1980s. 36 Several initial case series 1 , 9 , 11 , 14 , 20 , 27 , 33 , 35 led to a multicenter, randomized controlled trial (SANTE trial) demonstrating a significant and sustained efficacy of anterior nucleus DBS. 7 , 31 Anterior nucleus DBS currently involves a duty cycle with stimulation on for 1 minute and off for 4 or 5 minutes irrespective of seizure onset. 15 With the approval of a responsive neurostimulation system (Neuropace Inc.), there is renewed interest in exploring the feasibility of