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Marc N. Gallay, David Moser, and Daniel Jeanmonod

T he first clinical study with incisionless transcranial MR-guided high-intensity focused ultrasound in the field of functional neurosurgery was published by Martin et al. in 2009. Since publication of this first trial, around 200 treatments have been reported. As each reported series has small numbers, 8 , 11 , 12 , 14 , 19 , 20 , 24 , 26 , 28 , 40 , 41 , 44 no procedure-related risk profile can be reliably inferred yet. To assess risks, one also needs an analysis of targeting accuracy, which is directly related to the risk of damage to neighboring structures