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Jacob A. Miller, Ehsan H. Balagamwala, Samuel T. Chao, Todd Emch, John H. Suh, Toufik Djemil, and Lilyana Angelov

the context of myeloma-associated vertebral fractures, metastatic bone disease, and SRS. 10 , 23 , 41 BPI scores were recorded as the “worst,” “current,” and “average” pain (ranging from 0 to 10) at each treatment site throughout clinical follow-up. Pain relief and symptomatic failure were adjusted for narcotic usage per Radiation Therapy Oncology Group (RTOG) study 0631. 35 Any increase in narcotic utilization was considered pain progression. Pre-SRS BPI scores were compared with 1-month and 3-month post-SRS scores. Secondary outcome variables included the

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J. Bradley Elder and E. Antonio Chiocca

demonstrate a potential benefit of radiation and concomitant chemotherapy following resection for GBM in patients with a poor performance status. This study has limitations inherent to a retrospective review. Of significant concern is the fact that the study patients were identified through reviews of radiation oncology and pathology databases. Thus, all patients had been referred for treatment and were presumably deemed healthy enough by their physician to merit this referral. This selection bias weakens the conclusions of the study but also underscores the need for

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Ehsan H. Balagamwala, Lilyana Angelov, Shlomo A. Koyfman, John H. Suh, Chandana A. Reddy, Toufik Djemil, Grant K. Hunter, Ping Xia, and Samuel T. Chao

involvement of the epidural space or posterior elements as the disease progresses. Symptoms of metastasis to the spine can range from pain to motor dysfunction to severe neurological compromise due to spinal cord compression from progressive epidural disease. 8 Treatment of spinal metastases from RCC requires multispecialty management by medical, surgical, and radiation oncology teams. Patients with no neurological compromise benefit most from pain management using narcotic and/or nonnarcotic analgesics, as well as radiation therapy (CRT or SBRT). Surgical intervention is

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Rupesh Kotecha, Camille A. Berriochoa, Erin S. Murphy, Andre G. Machado, Samuel T. Chao, John H. Suh, and Kevin L. Stephans

, : Measurements of RF heating during 3.0-T MRI of a pig implanted with deep brain stimulator . Magn Reson Imaging 31 : 783 – 788 , 2013 4 Gossman MS , Paralikar KJ , Hebb AO , Wilkinson JD , Graves-Calhoun AR , Lawson RC , : Effects on radiation oncology treatments involving various neuromodulation devices . J XRay Sci Technol 19 : 443 – 456 , 2011 5 Gossman MS , Wilkinson JD , Mallick A : Treatment approach, delivery, and follow-up evaluation for cardiac rhythm disease management patients receiving radiation therapy: retrospective

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Ovidiu Marina, John H. Suh, Chandana A. Reddy, Gene H. Barnett, Michael A. Vogelbaum, David M. Peereboom, Glen H. J. Stevens, Heinrich Elinzano, and Samuel T. Chao

radiation therapy. Patients were then stratified by RTOG RPA class 8 and treatment intervention to better compare the effectiveness of the interventions. Methods Patient Population Patients evaluated for GBM at the Cleveland Clinic were retrospectively identified from databases provided by the Departments of Radiation Oncology and Pathology. The institutional review board at the same institution approved the study. Hospital charts and radiation records were reviewed, with patients being included in the study if they had a pathology report confirming the GBM

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Jacob A. Miller, Ehsan H. Balagamwala, Lilyana Angelov, John H. Suh, Brian Rini, Jorge A. Garcia, Manmeet Ahluwalia, and Samuel T. Chao

carcinoma cells to radiotherapy and chemotherapy . Cancer Biol Ther 13 : 401 – 407 , 2012 Disclosures Dr. Suh reports receiving support for travel and lodging and/or research from Elekta and Varian Medical Systems. Dr. Rini reports a consultant relationship with Pfizer. Dr. Garcia reports a consultant relationship with Astellas Pharma US, Inc.; Bayer Healthcare Pharmaceuticals, Inc.; Pfizer, Inc.; and Sanofi S.A. Dr. Ahluwalia reports a consultant relationship with Incyte Corp. and PrIME Oncology, Inc. Dr. Chao reports honorarium receipt from Varian

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Vikram B. Chakravarthy, Hammad A. Khan, Shaarada Srivatsa, Todd Emch, Samuel T. Chao, and Ajit A. Krishnaney

the tumor and spinal cord and was therefore not measured in patients with lumbosacral disease. In accordance with preliminary Spine Response Assessment in Neuro-Oncology (SPINO) group recommendations, LP was defined as any measurable unidimensional increase in epidural disease. 19 LP, ALTP, and ALTP-E were assessed using post-SSRS MRI in reference to postoperative, pre-SSRS MRI. All SSRS contours were created in accordance with consensus guidelines, using either postoperative MRI or CT myelograms if MRI was suboptimal for contouring. 20 The adjacent level was

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E. Emily Bennett, Camille Berriochoa, Ghaith Habboub, Scott Brigeman, Samuel T. Chao, and Lilyana Angelov

– 116 , 2012 13 Seung SK , Larson DA , Galvin JM , Mehta MP , Potters L , Schultz CJ , : American College of Radiology (ACR) and American Society for Radiation Oncology (ASTRO) Practice Guideline for the Performance of Stereotactic Radiosurgery (SRS) . Am J Clin Oncol 36 : 310 – 315 , 2013 14 Shin DA , Huh R , Chung SS , Rock J , Ryu S : Stereotactic spine radiosurgery for intradural and intramedullary metastasis . Neurosurg Focus 27 : 6 E10 , 2009 Disclosures The authors report no conflict of interest concerning

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Robert J. Weil, Gaurav G. Mavinkurve, Samuel T. Chao, Michael A. Vogelbaum, John H. Suh, Matthew Kolar, and Steven A. Toms

, Podgorsak MB , Harris E , Price RA Jr , Bevan A , : American Society for Therapeutic Radiology and Oncology (ASTRO) emerging technology committee report on electronic brachytherapy . Int J Radiat Oncol Biol Phys 76 : 963 – 972 , 2010 30 Patchell RA , Tibbs PA , Regine WF , Dempsey RJ , Mohiuddin M , Kryscio RJ , : Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial . JAMA 280 : 1485 – 1489 , 1998 31 Patchell RA , Tibbs PA , Walsh JW , Dempsey RJ , Maruyama Y

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Rupesh Kotecha, Lilyana Angelov, Gene H. Barnett, Chandana A. Reddy, John H. Suh, Erin S. Murphy, Gennady Neyman, and Samuel T. Chao

primary treatment of lesions localized in the calvaria or skull base. We also describe a novel bolus-based treatment technique that we developed to treat superficial lesions in the calvarial bones. Methods We reviewed databases from the Cleveland Clinic Burkhardt Brain Tumor and Neuro-Oncology Center and Department of Radiation Oncology and identified 21 patients who had undergone GKS for calvarial and skull base metastases during 2001–2013. The metastatic lesions were classified by their originating site: calvaria or skull base. Lesions in the frontal, parietal